Homeodomain Interacting Protein Kinase (HPK-1) is Required in the Soma for Robust Germline Proliferation in C. elegans
Homeodomain Interacting Protein Kinase (HPK-1) is Required in the Soma for Robust Germline Proliferation in C. elegans
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DOI：
10.1002/dvdy.24023
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发表时间：
2013-11-01
影响因子：
2.5
通讯作者：
Nicholas, Hannah R.
中科院分区：
文献类型：
--
作者：
Berber, Slavica;Llamosas, Estelle;Nicholas, Hannah R.
背景：紧密调控的通路维持干细胞群内增殖和分化之间的平衡。在秀丽隐杆线虫中，生殖系是唯一由干细胞样细胞维持到成年的组织。在当前的研究中，我们研究了丝氨酸/苏氨酸激酶同源结构域相互作用蛋白激酶（HIPK）家族成员HPK-1在C.结果：我们报道了HPK-1在发育和成年期促进生殖细胞增殖所必需的。此外，我们表明，HPK-1是必需的索马调节生殖细胞增殖。我们还表明，HPK-1是一个主要的核蛋白表达在几个体细胞组织，包括种系相互作用的体细胞cells.Conclusions：我们的观察是一致的HIPKs在细胞增殖的控制和确定一个新的背景下，这种控制在生殖细胞增殖的保守作用。Developmental Dynamics 242：1250-1261，2013. (c)2013 Wiley Periodicals，Inc.
Background: Tightly regulated pathways maintain the balance between proliferation and differentiation within stem cell populations. In Caenorhabditis elegans, the germline is the only tissue that is maintained by stem-like cells into adulthood. In the current study, we investigated the role played by a member of the Homeodomain interacting protein kinase (HIPK) family of serine/threonine kinases, HPK-1, in the development and maintenance of the C. elegans germline.Results: We report that HPK-1 is required for promotion of germline proliferation during development and into adulthood. Additionally, we show that HPK-1 is required in the soma for regulation of germline proliferation. We also show that HPK-1 is a predominantly nuclear protein expressed in several somatic tissues including germline-interacting somatic cells.Conclusions: Our observations are consistent with a conserved role for HIPKs in the control of cellular proliferation and identify a new context for such control in germ cell proliferation. Developmental Dynamics 242:1250-1261, 2013. (c) 2013 Wiley Periodicals, Inc.