EVALUATION OF NEUTRON AMBIENT DOSE EQUIVALENT IN INTENSITY-MODULATED COMPOSITE PARTICLE THERAPY
EVALUATION OF NEUTRON AMBIENT DOSE EQUIVALENT IN INTENSITY-MODULATED COMPOSITE PARTICLE THERAPY
复制标题
调强复合粒子治疗中子环境剂量当量的评估
DOI：
10.1093/rpd/ncab031
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发表时间：
2021
影响因子：
1
通讯作者：
Yonai Shunsuke
中科院分区：
文献类型：
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作者：
Matsumoto Shinnosuke;Yonai Shunsuke
几项研究报告了使用各种重离子束治疗癌症的好处。根据这些报告，美国国家量子与放射科学技术研究院开始开发使用氦离子、碳离子、氧离子和氖离子的强度调制复合粒子疗法 (IMPACT)。在离子束治疗中，束线装置或患者中的核相互作用产生二次中子。本研究评估了 IMPACT 中二次中子的特性。使用 WENDI-II 测量中子环境剂量当量。测量是在实际情况下使用 He、C、O 和 Ne 离子束进行的。此外，将 He、C、O 和 Ne 离子束产生的中子环境剂量当量与质子治疗中的中子环境剂量当量进行了比较。即使初级离子不同，距离依赖性也不存在差异。高原子序数的一次离子束产生的中子倾向于向前发射。此外，与质子治疗相比，IMPACT可以减少中子剂量。
Several studies have reported benefits derived from cancer treatment using various heavy-ion beams. Based on these reports, the National Institutes for Quantum and Radiological Science and Technology started developing intensity-modulated composite particle therapy (IMPACT) using He-, C-, O-, and Ne-ions. In ion beam therapy, nuclear interactions in the beamline devices or patient produce secondary neutrons. This study evaluated the characteristics of secondary neutrons in IMPACT. Neutron ambient dose equivalents were measured using WENDI-II. Measurements were performed under realistic case scenarios using He-, C-, O- and Ne-ion beams. Moreover, neutron ambient dose equivalents generated by He-, C-, O- and Ne-ion beams were compared with neutron ambient dose equivalents in proton therapy. No differences exist in the distance-dependence even when the primary ions are different. Neutrons generated by primary ion beams of high atomic numbers tend to emit forward. Moreover, in contrast with proton therapy, IMPACT can reduce neutron doses.