The potential use of cell-based therapies in the treatment of oral diseases.
The potential use of cell-based therapies in the treatment of oral diseases.
复制标题
基于细胞的疗法在口腔疾病治疗中的潜在用途。
DOI：
10.1111/odi.12320
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发表时间：
2015
期刊：
影响因子：
3.8
通讯作者：
Kagami H
中科院分区：
文献类型：
--
作者：
Yamada S;Uchida K;Iwamoto Y;Sugino N;Yoshinari N;Kagami H;Taguchi A;Kagami H
最近医学上一个令人兴奋的发展是使用活细胞治疗病人。活细胞治疗疾病的效用首先在白血病患者的造血干细胞移植中得到证实。这种方法已经扩展到其他疾病，如糖尿病患者的胰岛移植。在这些情况下，细胞从供体或患者中分离出来，无需复杂的操作即可使用。自20世纪80年代以来，细胞已经在体外扩增，用于治疗烧伤患者的皮肤。这种新的治疗策略被称为“组织工程”，并已成功应用于皮肤，软骨和骨缺损的治疗。近年来，随着干细胞科学的发展，这一领域受到了广泛的关注，其应用范围也不断扩大。在这篇综述中，以细胞为基础的治疗口腔疾病的潜力进行了讨论，并简要回顾了这一领域的最新进展。
A recent and exciting development in medicine is the use of living cells for patient treatment. The utility of living cells to treat diseases was first proved in hematopoietic stem cell transplantation for leukemia patients. This approach has been expanded for other diseases such as islet transplantation for diabetic patients. In those cases, the cells were isolated from donors or the patient and used without complex manipulation. Since the 1980s, cells have been expanded outside of the body for the treatment of burn patients’ skin. This novel treatment strategy is designated ‘tissue engineering’ and has been successfully applied for treatment of skin, cartilage, and also bone defects. Due to the recent developments in stem cell science, this area has attracted much attention and the application has been expanding. In this review, the potential of cell‐based therapy for oral diseases is discussed with a concise review of recent developments in this field.