Brain artery diameters and risk of dementia and stroke.
Brain artery diameters and risk of dementia and stroke.
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脑动脉直径与痴呆和中风的风险。
DOI：
10.1002/alz.13712
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
T
中科院分区：
文献类型：
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作者：
Melgarejo,JesusD;Gurel,Kursat;Compton,CassidyRose;Liu,Minghua;Guzman,Vanessa;Assuras,Stephanie;Levin,BonnieE;Elkind,MitchellSV;Ikram,MKamran;Kavousi,Maryam;Ikram,MArfan;Wright,Clinton;Crivello,Fabrice;Laurent,Alexandre;T
我们使用常规T2加权脑磁共振成像(MRI)图像在三个不同的基于人群的研究中测试了脑动脉直径与痴呆和中风风险的关系。方法我们包括来自三个纵向人群研究的8420名40岁的成年人，他们进行了脑部MRI扫描。我们估计并荟萃分析了与痴呆症和中风相关的大脑、颈动脉和基底动脉直径的风险比(HR)。结果总体和颈动脉直径和第95百分位数分别使痴呆症的风险增加1.74倍(95%可信区间，1.13-2.68)和1.48倍(95%可信区间，1.12-1.96)。对于中风，荟萃分析得出整体动脉的相对危险度为1.59(95%可信区间，1.04-2.42)，基底动脉直径的比值比为2.11(95%可信区间，1.45-3.08)。我们的发现强调了基于T2加权脑MRI的脑直径评估在评估痴呆和中风风险方面的潜在价值。
INTRODUCTIONWe tested the association of brain artery diameters with dementia and stroke risk in three distinct population‐based studies using conventional T2‐weighted brain magnetic resonance imaging (MRI) images.METHODSWe included 8420 adults > 40 years old from three longitudinal population‐based studies with brain MRI scans. We estimated and meta‐analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke.RESULTOverall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13–2.68) and 1.48 (95% CI, 1.12–1.96) fold, respectively. For stroke, meta‐analyses yielded HRs of 1.59 (95% CI, 1.04–2.42) for overall arteries and 2.11 (95% CI, 1.45–3.08) for basilar artery diameters > 95th percentile.DISCUSSIONIndividuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2‐weighted brain MRI‐based brain diameter assessment in estimating the risk of dementia and stroke.