Phosphoinositides in membrane traffic

Phosphoinositides in membrane traffic
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DOI:
10.1016/s0955-0674(99)80066-0
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发表时间:
1999-08-01
影响因子:
7.5
通讯作者:
Stenmark, H
Stenmark, H
中科院分区:
生物学2区
文献类型:
--
作者:
Corvera, S;D'Arrigo, A;Stenmark, H

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磷酸肌醇作为控制膜运输的蛋白质机器的直接局部调节剂或招募剂。在过去的一年中,磷酸肌醇效应物的例子包括外壳组装中小 GTP 酶的调节剂、网格蛋白包被囊泡形成中的动力和内吞膜运输中的 FYVE 指蛋白。一种新型磷酸肌醇似乎可以调节参与多囊泡内体形成的效应物。
Phosphoinositides serve as direct local modulators or recruiters of the protein machineries that control membrane trafficking. In the past year, examples of phosphoinositide effecters include regulators of small GTPases in coat assembly, dynamin in clathrin coated vesicle formation and FYVE finger proteins in endocytic membrane traffic. A novel phosphoinositide appears to regulate effecters involved in the formation of multivesicular endosomes.