EFFECTS OF ESTRADIOL AND PROGESTERONE ON FOOD-INTAKE, BODY-WEIGHT, AND CARCASS ADIPOSITY IN WEANLING RATS
EFFECTS OF ESTRADIOL AND PROGESTERONE ON FOOD-INTAKE, BODY-WEIGHT, AND CARCASS ADIPOSITY IN WEANLING RATS
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DOI：
10.1152/ajpendo.1981.240.5.e499
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发表时间：
1981-01-01
影响因子：
--
通讯作者：
WADE, GN
中科院分区：
文献类型：
--
作者：
SCHWARTZ, SM;WADE, GN
研究了雌二醇和黄体酮对断奶雌性大鼠的食物摄入量、体重、胴体肥胖度和脂肪组织脂蛋白脂肪酶（LDL）活性的影响。与成人一样，苯甲酸雌二醇 (EB) 治疗可减少卵巢切除 (OVX) 断奶仔猪的体重增加。断奶仔猪对 EB 的其他反应减弱或消失。 EB 治疗不会减少食物摄入、胴体肥胖或脂肪组织 LPL 活性。这种对 EB 的反应性受损可能是由于断奶仔猪肝脏和脂肪组织（但不是下丘脑）中细胞质雌激素受体水平下降所致。断奶仔猪对黄体酮的反应与成人相似。用黄体酮治疗 OVX、EB 引发的断奶仔猪可增加食物摄入量、体重增加和胴体肥胖。这种对黄体酮的成人反应与脂肪组织孕激素受体的成人水平有关。黄体酮治疗并没有增加断奶仔猪脂肪组织 LPL 活性，表明 LPL 活性的变化对于黄体酮诱导的肥胖不是必需的。
The effects of estradiol and progesterone on food intake, body weight, carcass adiposity and adipose tissue lipoprotein lipase (LDL) activity were investigated in weanling female rats. Treatment with estradiol benzoate (EB) reduced body weight gain in ovariectomized (OVX) weanlings as it does in adults. Other responses to EB were attenuated or absent in weanlings. EB treatment did not reduce food intake, carcass adiposity, or adipose tissue LPL activity. This impaired responsiveness to EB may be due to decreased levels of cytoplasmic estrogen receptors in liver and adipose tissue (but not hypthalamus) in weanlings. Responsiveness to progesterone was adultlike in weanlings. Treatment of OVX, EB-primed weanlings with progesterone increased food intake, body weight gain, and carcass adiposity. This adultlike responsiveness to progesterone was associated with adultlike levels of adipose tissue progestin receptors. Progesterone treatment did not increase adipose tissue LPL activity in weanlings, indicating that changes in LPL activity are not necessary for progesterone-induced obesity.