Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts.
Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts.
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DOI：
10.1186/1475-2875-10-s1-s5
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发表时间：
2011-03-15
期刊：
影响因子：
3
通讯作者：
Ginsburg H
中科院分区：
文献类型：
--
作者：
Deharo E;Ginsburg H
在从民族植物学来源寻找抗疟药的过程中，对植物提取物进行化学分级，并通过生物学试验指导分离纯活性化合物。为了确定分离的活性化合物对粗提取物的整体抗疟原虫活性的响应性，扫描该领域的文献，并定量分析结果以发现纯化合物对整体提取物活性的贡献。人们发现，一般来说，分离的分子的活性不能解释自己的活性的粗提取物。建议未来的研究应考虑“药物旁边的药物”，寻找那些能够提高分离的活性化合物的活性的产品（否则将沿着分馏过程被丢弃）。
In the search for antimalarials from ethnobotanical origin, plant extracts are chemically fractionated and biological tests guide the isolation of pure active compounds. To establish the responsibility of isolated active compound(s) to the whole antiplasmodial activity of a crude extract, the literature in this field was scanned and results were analysed quantitatively to find the contribution of the pure compound to the activity of the whole extract. It was found that, generally, the activity of isolated molecules could not account on their own for the activity of the crude extract. It is suggested that future research should take into account the “drugs beside the drug”, looking for those products (otherwise discarded along the fractionation process) able to boost the activity of isolated active compounds.