Homovanillic acid in caudate and pre-frontal cortex following neuroleptics.
Homovanillic acid in caudate and pre-frontal cortex following neuroleptics.
复制标题
服用抗精神病药物后，尾状核和前额皮质中的高香草酸。
DOI：
10.1016/0014-2999(84)90438-2
复制
发表时间：
1984
影响因子：
5
通讯作者：
BowersJr,MB
中科院分区：
文献类型：
--
作者：
BowersJr,MB
高香草酸（HVA）测定大鼠尾状核和前额叶皮层3小时后，单剂量的各种抗精神病药物。硫利达嗪，氟哌啶醇，氟奋乃静，甲氧氯普胺增加HVA水平在尾状核比在前额叶皮层，而舒必利和氯氮平产生更大的增加HVA在前额叶皮层。这些结果与大鼠前额叶皮层多巴胺自身受体相对缺乏的假设一致。
Homovanillic acid (HVA) was measured in rat caudate and pre-frontal cortex 3 h following a single dose of a variety of neuroleptics. Thioridazine, haloperidol, fluphenazine, and metoclopramide increased HVA levels in caudate more than in pre-frontal cortex; whereas sulpiride and clozapine produced greater increases in HVA in pre-frontal cortex. These results are consistent with the proposal that rat pre-frontal cortex is relatively deficient in dopamine autoreceptors.