Modification of Timolol Release From Silicone Hydrogel Model Contact Lens Materials Using Hyaluronic Acid
Modification of Timolol Release From Silicone Hydrogel Model Contact Lens Materials Using Hyaluronic Acid
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DOI：
10.1097/icl.0000000000000033
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发表时间：
2014-09-01
影响因子：
2.3
通讯作者：
Sheardown, Heather
中科院分区：
文献类型：
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作者：
Guidi, Giuliano;Korogiannaki, Myrto;Sheardown, Heather
目的：研究透明质酸(HA)作为功能性添加剂在模型硅胶隐形眼镜中的作用。方法：以甲基丙烯酸羟乙酯(HEMA)与三甲基硅氧丙基硅烷(Tris)按9：1(wt：wt)的比例或N，N-二甲基丙烯酰胺(DMA)与tris按1：1(wt：wt)的比例制备模型隐形眼镜。以乙二醇二甲基丙烯酸酯(EGDMA)为交联剂。研究了四种不同的模型晶状体成分：未修饰的对照组，含有HA的晶状体，带有马来酸噻吗洛尔分子印迹的晶状体，以及既有印迹又含有HA的晶状体。结果：透明质酸在这些模型隐形眼镜中具有作为功能性添加剂的能力，显著增加了药物的载药量和释放量。这种能力似乎独立于分子印迹，但其效果与模型晶状体中HA的浓度和用于促进摄取的载药液浓度有关。结论：透明质酸虽然不同于典型的分子印迹功能单体，但可以作为一种有用的添加剂来改善硅胶水凝胶模型的药物释放质量。
Objectives: The ability of hyaluronic acid (HA) to act as a functional additive in model silicone hydrogel contact lenses to alter the uptake and release characteristics of timolol was investigated.Methods: Model contact lenses were prepared using 2 primary formulations: 2-hydroxyethyl methacrylate (HEMA) with 3-methacryloxypropyltris (trimethylsiloxy) silane (TRIS) in a 9:1 (wt:wt) ratio or N,N-dimethylacrylamide (DMA) with TRIS in a 1:1 (wt:wt) ratio. Ethylene glycol dimethacrylate (EGDMA) was used as the cross-linker. Four different model lens compositions were explored: unmodified controls, lenses containing HA, lenses that were molecularly imprinted with timolol maleate, and those that were both imprinted and contained HA. Model lenses were then used in subsequent materials characterization, drug loading, and drug release studies.Results: Hyaluronic acid was shown to have the ability to act as a functional additive in these model contact lenses, significantly increasing the drug loading and release mass. This ability seemed to be independent of molecular imprinting, but its efficacy was related to the concentration of HA contained within model lenses and the concentration of drug loading solution used to facilitate uptake. Timolol release was sustained for a duration of approximately 2 days, and the dose of drug was shown to be controlled by both HA-drug interactions and molecular imprinting within the silicone hydrogels.Conclusions: Hyaluronic acid, although different than typical functional monomers used in molecular imprinting, can be a useful additive to modify the mass of drug release from model silicone hydrogel lenses.