Sleep and treatment prediction in endogenous depression.
Sleep and treatment prediction in endogenous depression.
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内源性抑郁症的睡眠和治疗预测。
DOI：
10.1176/ajp.138.4.429
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Shaw,DH
中科院分区：
文献类型：
--
作者：
Kupfer,DJ;Spiker,DG;Coble,PA;Neil,JF;Ulrich,R;Shaw,DH
抑郁症临床反应的预测主要基于临床症状和病史。最近，心理生物学的措施已被用来提高临床预测的准确性。在34例接受阿米替林治疗的原发性内源性抑郁症患者中，单独应用EEG监测的睡眠标准在预测临床反应方面比单独应用临床状态更有意义。阿米替林给药后REM潜伏期延长和入睡困难减少是影响该预测方程的主要睡眠变量。这些数据表明，内源性抑郁症患者在使用三环类抗抑郁药进行“药理学探索”后，临床结局与心理生物学特征之间存在密切关系。
The prediction of clinical response in depression has been based primarily on clinical symptoms and history. Recently, psychobiologic measures have been used to increase the accuracy of clinical prediction. In 34 drug-free patients with primary endogenous depression treated with amitriptyline, the application of EEG-monitored sleep criteria alone was more significant than clinical status alone in the prediction of clinical response. Prolonged REM latency and reduced difficulty in sleep onset following the administration of amitriptyline were the main sleep variables contributing to this prediction equation. These data suggest a strong relationship between clinical outcome and psychobiologic profile in patients with endogenous depression after a" pharmacologic probe" with a tricyclic antidepressant.