NEWLY IDENTIFIED GLUTAMATE INTERNEURONS AND THEIR ROLE IN LOCOMOTION IN THE LAMPREY SPINAL-CORD
NEWLY IDENTIFIED GLUTAMATE INTERNEURONS AND THEIR ROLE IN LOCOMOTION IN THE LAMPREY SPINAL-CORD
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DOI：
10.1126/science.3563512
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发表时间：
1987-04-17
期刊：
影响因子：
56.9
通讯作者：
GRILLNER, S
中科院分区：
文献类型：
--
作者：
BUCHANAN, JT;GRILLNER, S
现在已经描述了一类新的兴奋性运动前中间神经元，它们对于七鳃鳗 [Ichthyomyzon unicuspis] 运动的产生非常重要。在孤立的脊髓中，这些神经元在虚构的游泳过程中与其突触后运动神经元同时起作用。它们小而数量多，并且单突触刺激运动神经元和抑制性前运动中间神经元。兴奋性突触后电位被兴奋性氨基酸拮抗剂抑制。这些中间神经元接收来自脑干的网状脊髓输入和来自皮肤传入的多突触输入。现在可以为七鳃鳗提出基于这些神经元突触相互作用的运动网络模型。
A new class of excitatory premotor interneurons that are imporant in the generation of locomotion in the lamprey [Ichthyomyzon unicuspis] has now been described. In the isolated spinal cord, these neurons act simultaneously with their postsynaptic motoneurons during fictive swimming. They are small and numerous, and they monosynaptically excite both motoneurons and inhibitory premotor interneurons. The excitatory postsynaptic potentials are depressed by an antagonist of excitatory amino acids. These interneurons receive reticulospinal input from the brain stem and polysynaptic input from skin afferents. A model of the network underlying locomotion based on the synaptic interactions of these neurons can now be proposed for the lamprey.