CHOLECYSTOKININ DECREASES FOOD INTAKE IN RATS
CHOLECYSTOKININ DECREASES FOOD INTAKE IN RATS
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DOI：
10.1037/h0034870
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发表时间：
1973-01-01
期刊：
影响因子：
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通讯作者：
SMITH, GP
中科院分区：
文献类型：
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作者：
GIBBS, J;YOUNG, RC;SMITH, GP
用120只成年雄性SD大鼠测定胆囊收缩素（CCK）的作用。部分纯化的CCK腹腔注射到禁食的Ss之前的食物介绍。该激素对固体和液体饮食的摄入产生了较大的剂量相关抑制。相同剂量的胆囊收缩素的合成末端八肽产生相同的结果。有效剂量的CCK没有抑制饮水后剥夺。治疗的SS没有出现疾病，也没有体温过高;无论是CCK还是八肽产生的学习的味觉厌恶在诱饵害羞测试。CCK的作用不是所有肠道激素的特性，因为注射促胰液素不影响进食。这些研究提出了CCK在摄食行为的短期控制中起抑制作用的可能性。(25参考文献）（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Tested the effects of cholecystokinin (CCK) on a total of 120 adult male Sprague-Dawley rats. Partially purified CCK was injected intraperitoneally into fasted Ss prior to food presentation. The hormone produced a large dose-related suppression of intake of solid and liquid diets. Identical doses of the synthetic terminal octapeptide of cholecystokinin produced identical results. An effective dose of CCK did not suppress drinking after water deprivation. Treated Ss did not appear ill and were not hyperthermic; neither CCK nor the octapeptide produced learning of a taste aversion in bait-shyness tests. The effect of CCK is not a property of all gut hormones, since injections of secretin did not affect feeding. These studies raise the possibility that CCK plays an inhibitory role in the short-term control of feeding behavior.(25 ref.)(PsycINFO Database Record (c) 2016 APA, all rights reserved)