Hepatitis B and C virus serologies among Japanese Americans with hepatocellular carcinoma.
Hepatitis B and C virus serologies among Japanese Americans with hepatocellular carcinoma.
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患有肝细胞癌的日裔美国人中的乙型和丙型肝炎病毒血清学。
DOI：
10.1093/infdis/173.6.1474
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Tabor,E
中科院分区：
文献类型：
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作者：
Nomura,A;Stemmermann,GN;Chyou,PH;Tabor,E
1967年至1970年间，5924名日裔美国男性接受了肝细胞癌（HCC）检查。到1992年，本组有24例HCC组织学确诊。对24名HCC男性患者和72名年龄匹配的对照组的冷冻血清样本进行了乙型肝炎表面抗原（HBsAg）、乙型肝炎核心抗原抗体、HBsAg抗体和丙型肝炎病毒抗体的检测。24例HCC中有15例（62.5%）检测到HBsAg，而72例对照中有2例（2.8%）检测到HBsAg（优势比为43.0；95%可信区间为5.7-325.5）。所有病例均无丙型肝炎病毒抗体，对照组仅有1例。这项研究表明，在夏威夷的日本裔男性中，肝细胞癌与乙型肝炎病毒感染之间存在很强的关联，但与丙型肝炎病毒感染无关。
A cohort of 5924 Japanese American men was examined between 1967 and 1970 for hepatocellular carcinoma (HCC). By 1992, 24 incident cases of HCC were histologically confirmed in the group. Frozen serum samples from the 24 men with HCC and 72 age-matched controls were tested for hepatitis B surface antigen (HBsAg), antibodies to hepatitis B core antigen, antibodies to HBsAg, and antibodies to hepatitis C virus. HBsAg was detected in 15 (62.5%) of 24 HCC cases compared with 2 (2.8%) of 72 controls (odds ratio, 43.0; 95% confidence interval, 5.7–325.5). None of the cases and only 1 control had antibody to hepatitis C virus. This study demonstrates a strong association between hepatocellular carcinoma and hepatitis B virus infection, but not with hepatitis C virus infection, among men of Japanese ancestry in Hawaii.