An outbreak of necrotizing enterocolitis associated with a novel Clostridium species in a neonatal intensive care unit
An outbreak of necrotizing enterocolitis associated with a novel Clostridium species in a neonatal intensive care unit
复制标题
DOI：
10.1086/341929
复制
发表时间：
2002-09-01
影响因子：
11.8
通讯作者：
Harding, GKM
中科院分区：
文献类型：
--
作者：
Alfa, MJ;Robson, D;Harding, GKM
6例新生儿在2个月内发生坏死性小肠结肠炎（NEC）。其中3例新生儿的血液培养物生长出了相同的菌株，似乎是一种新的梭菌属，已提出将其命名为“Clostridium acetatale”。在我们的重症监护和中级护理托儿所进行了一项使用直肠拭子的点患病率调查，结果表明20.8%的新生儿携带相同的“C。尽管没有NEC的证据。总之，我们描述了一个爆发的NEC与新的物种，我们认为，在较大的新生儿，这种类型的梭菌物种的运输可能是一个必要的步骤，在NEC的多阶段发病机制。
An outbreak of necrotizing enterocolitis (NEC) occurred in 6 neonates within a 2-month period. Blood cultures from 3 of these neonates grew the same strain of what appears to be a novel clostridial species for which the name "Clostridium neonatale" has been proposed. A point-prevalence survey that used rectal swabs was performed in our intensive-care and intermediate-care nurseries, and it indicated that 20.8% of neonates carried this same "C. neonatale" strain despite having no evidence of NEC. In conclusion, we describe an outbreak of NEC associated with the novel species, and we suggest that, in larger neonates, carriage of this type of Clostridium species may be a necessary step in the multistage pathogenesis of NEC.