COMPARISON OF ONCE-DAILY INTRAVENOUS AND ORAL OMEPRAZOLE ON PENTAGASTRIN-STIMULATED ACID-SECRETION IN DUODENAL-ULCER PATIENTS
COMPARISON OF ONCE-DAILY INTRAVENOUS AND ORAL OMEPRAZOLE ON PENTAGASTRIN-STIMULATED ACID-SECRETION IN DUODENAL-ULCER PATIENTS
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DOI：
10.1159/000200992
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发表时间：
1992-11-01
期刊：
影响因子：
3.2
通讯作者：
OLBE, L
中科院分区：
文献类型：
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作者：
CEDERBERG, C;LIND, T;OLBE, L
本文对8例十二指肠溃疡患者每日1次口服奥美拉唑20 mg、静脉注射奥美拉唑40 mg，连续5天观察其对戊加司汀刺激胃酸分泌的影响。此外，在口服治疗期间的第6天，他们还接受了10毫克的静脉注射剂量。在给药后6-7小时测量抗分泌效果，在给药间隔期间的最大抑制时间点测量。在20 mg p.o治疗期间，对峰值酸输出（PAO）的抑制率中位数从第1天的43%显著增加到第5天的100%。第一次40 mg静脉注射剂量在第1天已经产生了98%的PAO抑制。给药5天后，抑制率达到100%。另一方面，10毫克静脉注射剂量基本上可以维持口服治疗5天后达到的PAO减少程度。奥美拉唑的血浆浓度在20mg p.o.和40mg i.v.重复给药期间升高。
The effect of 5 days of once-daily dosing with 20 mg p.o. and 40 mg i.v. omeprazole on pentagastrin-stimulated acid secretion was studied in 8 patients with duodenal ulcer. In addition they also received a 10-mg i.v. dose on day 6 during the oral treatment period. The antisecretory effect was measured 6-7 h after dose at a time point when maximal inhibition during the dosing interval is anticipated. The median percent inhibition of peak acid output (PAO) markedly increased from 43% on day 1 to 100% on day 5 during treatment with 20 mg p.o. The first 40-mg i.v. dose produced a median inhibition of 98% of PAO already on day 1. After 5 days of dosing, the inhibition had increased to 100%. On the other hand, a 10-mg i.v. dose could essentially maintain the degree of PAO reduction reached after 5 days of oral treatment. Plasma omeprazole concentrations increased during repeated dosing both with 20 mg p.o. and 40 mg i.v.