Mitochondrial DNA involvement in human longevity
Mitochondrial DNA involvement in human longevity
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DOI：
10.1016/j.bbabio.2006.05.040
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发表时间：
2006-09-01
影响因子：
4.3
通讯作者：
Franceschi, Claudio
中科院分区：
文献类型：
--
作者：
Santoro, Aurelia;Salvioli, Stefano;Franceschi, Claudio
这篇综述的主要信息可以概括如下：衰老和长寿，作为具有重要遗传成分的复杂性状，可能取决于许多与遗传和体细胞mtDNA变异相互作用的核基因变异。我们回顾了文献中的数据，特别关注人类的长寿，并认为我们对衰老和长寿的假设可能具有更广泛的相关性，并扩展到其他与年龄相关的复杂特征，如阿尔茨海默病和帕金森病。因此，包括衰老和长寿在内的复杂性状的遗传学甚至比以前认为的更复杂，核基因多态性与线粒体DNA变异之间的上位性相互作用（体细胞和遗传）以及mtDNA体细胞突变之间（组织特异性）和mtDNA遗传变异单倍群和亚单倍群必须被认为是能够解释衰老和长寿表型的一部分的额外参与者。验证这一假设是未来衰老和长寿遗传学的主要挑战之一。(c)2006 Elsevier B.V.保留所有权利。
The main message of this review can be summarized as follows: aging and longevity, as complex traits having a significant genetic component, likely depend on a number of nuclear gene variants interacting with mtDNA variability both inherited and somatic. We reviewed the data available in the literature with particular attention to human longevity, and argued that what we hypothesize for aging and longevity could have a more general relevance and be extended to other age-related complex traits such as Alzheimer's and Parkinson's diseases. The genetics which emerges for complex traits, including aging and longevity, is thus even more complicated than previously thought, as epistatic interactions between nuclear gene polymorphisms and mtDNA variability (both somatic and inherited) as well as between mtDNA somatic mutations (tissue specific) and mtDNA inherited variants (haplogroups and sub-haplogroups) must be considered as additional players capable of explaining a part of the aging and longevity phenotype. To test this hypothesis is one of the main challenge in the genetics of aging and longevity in the next future. (c) 2006 Elsevier B.V. All rights reserved.