Cancer Stem Cells in Oral Cavity Squamous Cell Carcinoma: A Review.
Cancer Stem Cells in Oral Cavity Squamous Cell Carcinoma: A Review.
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DOI：
10.3389/fonc.2017.00112
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发表时间：
2017
影响因子：
4.7
通讯作者：
Itinteang T
中科院分区：
文献类型：
--
作者：
Baillie R;Tan ST;Itinteang T
在口腔鳞状细胞癌(OCSCC)中发现了肿瘤干细胞。CSCs具有永久自我更新和增殖的能力，能够产生下游的祖细胞和癌细胞来驱动肿瘤的生长。包括口腔鳞状细胞癌在内的许多癌症类型的研究已经使用特定的标记物识别了肿瘤干细胞，但仍不清楚这些标记物在干细胞层次结构中的位置。OCSCC中存在多个CSC亚型，使得研究依赖于多个标记的使用，这进一步加剧了这一点。本文综述了肿瘤干细胞标志物OCT4、SOX2、NANOG、ALDH1、磷酸化STAT3、CD44、CD24、CD133和Musashi-1的研究现状，特别是它们在口腔鳞状细胞癌研究中的应用和有效性，以及如何将它们组织到CSC层次结构中。OCSCC CSCs还表达肾素-血管紧张素系统(RAS)的成分，这表明CSCs可能通过利用现有药物调节RAS而成为新的治疗靶点。
Cancer stem cells (CSCs) have been identified in oral cavity squamous cell carcinoma (OCSCC). CSCs possess the ability for perpetual self-renewal and proliferation, producing downstream progenitor cells and cancer cells that drive tumor growth. Studies of many cancer types including OCSCC have identified CSCs using specific markers, but it is still unclear as to where in the stem cell hierarchy these markers fall. This is compounded further by the presence of multiple CSC subtypes within OCSCC, making investigation reliant on the use of multiple markers. This review examines the current knowledge in CSC markers OCT4, SOX2, NANOG, ALDH1, phosphorylated STAT3, CD44, CD24, CD133, and Musashi-1, specifically focusing on their use and validity in OCSCC CSC research and how they may be organized into the CSC hierarchy. OCSCC CSCs also express components of the renin–angiotensin system (RAS), which suggests CSCs may be novel therapeutic targets by modulation of the RAS using existing medications.