DISTRIBUTION OF POLYAMINES IN HUMAN-EPIDERMIS
DISTRIBUTION OF POLYAMINES IN HUMAN-EPIDERMIS
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DOI：
10.1111/j.1365-2133.1985.tb02311.x
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发表时间：
1985-01-01
影响因子：
10.3
通讯作者：
ORTONNE, JP
中科院分区：
文献类型：
--
作者：
ELBAZE, P;MILANO, G;ORTONNE, JP
将表皮连续切片平行于表皮表面，用液相色谱法测定每一切片中多胺（PA）的浓度。PA浓度（以nmol/mg DNA表示）从最深层到更浅层不断降低。腐胺升高幅度最大（+83%）（P< 0.02），精脒和精胺升高幅度较小，分别为+30%（P< 0.05）和+27%（NS）。在基底层中的消化细胞具有高的多胺水平，并且随着它们在表层中成熟，它们的多胺含量降低。
Consecutive sections through the epidermis were cut parallel to its surface, and the polyamine (PA) concentration in each section was measured by liquid chromatography. There was a constant decrease in PA concentration (expressed as nmol/mg DNA) from the deepest layer to the more superficial layers. Putrescine showed the greatest increase (+83%) (P< 0.02): The elevations of spermidine and spermine levels were less marked, respectively +30% (P< 0.05) and + 27% (NS). Proliferating cells in the basal layer possess high polyamine levels and as they mature in the superficial layers their polyamine content decreases.