EFFECT OF DISODIUM CROMOGLYCATE (INTAL) ON SPUTUM PROTEIN COMPOSITION
EFFECT OF DISODIUM CROMOGLYCATE (INTAL) ON SPUTUM PROTEIN COMPOSITION
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DOI：
10.1136/thx.27.6.726
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发表时间：
1972-01-01
期刊：
影响因子：
10
通讯作者：
REBUCK, AS
中科院分区：
文献类型：
--
作者：
HEILPERN, S;REBUCK, AS
用凝胶电泳法比较了9例哮喘患者和11例非哮喘患者痰中蛋白质的含量。结果表明，哮喘患者痰中白蛋白含量显著高于非哮喘患者(P<0.01)。另有11名哮喘患者服用色甘酸钠(InTal)作为治疗的一部分，其痰白蛋白水平与非哮喘患者没有区别。然后对哮喘患者进行连续研究，在色甘酸钠治疗前后，白蛋白含量在开始治疗的两天内恢复到非哮喘水平。提示色甘酸二钠在改变痰蛋白方面具有以前未被认识到的作用。
The protein content in the sputum of nine patients with asthma was compared with that in 11 non-asthmatic patients by a method of gel electrophoresis. It was found that the albumin content was significantly higher in the sputum of the asthmatics than of the non-asthmatics (P<0·01). A further 11 asthmatic patients who were taking disodium cromoglycate (Intal) as part of their treatment had sputum albumin levels indistinguishable from the non-asthmatics. When patients with asthma were then studied serially, before and after disodium cromoglycate therapy, the albumin content returned to non-asthmatic levels within two days of starting treatment. It is suggested that disodium cromoglycate has a previously unrecognized action in altering sputum proteins.