Drinking and mortality: long-term follow-up of drinking-discordant twin pairs.
Drinking and mortality: long-term follow-up of drinking-discordant twin pairs.
复制标题
DOI：
10.1111/add.13152
复制
发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Kaprio J
中科院分区：
文献类型：
--
作者：
Sipilä P;Rose RJ;Kaprio J
确定饮酒与全因死亡率的关联是否在控制家族和遗传混淆的不一致单卵双胞胎比较中重复。30年前瞻性随访。基于人口的芬兰老年双胞胎队列。1981年底，年龄在24-60岁之间的同性双胞胎，没有明显的合并症，在1975年和1981年完成了问卷调查，回答率分别为89%和84%。从1981年返回问卷之日至2011年12月31日，共有15607对双胞胎可用于死亡率随访;分析了14787对双胞胎的完整信息。自我报告的每月饮酒量，大量饮酒的场合（HDO）和酒精引起的停电。根据年龄、性别、婚姻和吸烟状况、体育活动、肥胖、教育和社会阶层进行调整。在双胞胎个体中，高水平的每月饮酒量（≥ 259 g/月）与早期死亡率相关[风险比（HR）= 1.63，95%置信区间（CI）= 1.47-1.81]。在所有信息性饮酒不一致的双胞胎对（HR = 1.91，95%CI = 1.49-2.45）和不一致的单卵（MZ）双胞胎对（HR = 2.24，95%CI = 1.31-3.85）的比较中，这种关联得到了复制，效应量相当。较小样本的MZ双胞胎不一致的HDO和停电的权力有限，一个显着的关联与死亡率被发现为多次停电（HR = 2.82，95% CI = 1.30-6.08），但没有HDO。在芬兰双胞胎中，高水平的每月饮酒和酒精引起的停电与全因死亡率增加的关系不能用家族或遗传混乱来解释;这种解释似乎是因果关系。
To determine if associations of alcohol consumption with all-cause mortality replicate in discordant monozygotic twin comparisons that control for familial and genetic confounds. A 30-year prospective follow-up. Population-based older Finnish twin cohort. Same-sex twins, aged 24–60 years at the end of 1981, without overt comorbidities, completed questionnaires in 1975 and 1981 with response rates of 89 and 84%. A total of 15 607 twins were available for mortality follow-up from the date of returned 1981 questionnaires to 31 December 2011; 14 787 twins with complete information were analysed. Self-reported monthly alcohol consumption, heavy drinking occasions (HDO) and alcohol-induced blackouts. Adjustments for age, gender, marital and smoking status, physical activity, obesity, education and social class. Among twins as individuals, high levels of monthly alcohol consumption (≥ 259 g/month) associated with earlier mortality [hazard ratio (HR) = 1.63, 95% confidence interval (CI) = 1.47–1.81]. That association was replicated in comparisons of all informatively drinking-discordant twin pairs (HR = 1.91, 95% CI = 1.49–2.45) and within discordant monozygotic (MZ) twin pairs (HR = 2.24, 95% CI = 1.31–3.85), with comparable effect size. Smaller samples of MZ twins discordant for HDO and blackouts limited power; a significant association with mortality was found for multiple blackouts (HR = 2.82, 95% CI = 1.30–6.08), but not for HDO. The associations of high levels of monthly alcohol consumption and alcohol-induced blackouts with increased all-cause mortality among Finnish twins cannot be explained by familial or genetic confounds; the explanation appears to be causal.