An incident case-referent study on plasma enterolactone and breast cancer risk
An incident case-referent study on plasma enterolactone and breast cancer risk
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DOI：
10.1007/s00394-002-0373-3
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发表时间：
2002-08-01
影响因子：
5
通讯作者：
Hallmans, G
中科院分区：
文献类型：
--
作者：
Hultén, K;Winkvist, A;Hallmans, G
目的采用巢式病例-参照设计，评价血浆木脂素肠内酯水平与乳腺癌发病风险的关系。方法从瑞典北方的三个人群队列中选择248例病例和492例参考者。在入组时捐献血液样本。所有血液样本均储存在-80 ℃下。病例和参考对象的年龄、血样采集日期和采样中心相匹配。乳腺癌病例是通过区域和国家癌症登记处确定的。结果所有队列中吸烟者和其中一个队列中BMI 28的受试者的血浆肠内酯均较低< 23 and BMI >。低血浆肠内酯浓度，低于12.5（第）百分位数（平均血浆肠内酯2.9 nmol/l），与乳腺癌的风险增加。此外，血浆肠内酯高于87.5（第）百分位数（平均血浆肠内酯58.2 nmol/l）的高值与来自两个队列的女性乳腺癌风险增加显著相关，其中仅发生病例和绝经前女性人数较多。在一项乳腺癌筛查项目中，高血浆肠内酯浓度与乳腺癌风险的轻微降低无关。结论在所有三个队列中，极低的肠内酯血浆浓度与乳腺癌风险增加相关。在两个队列中，只有偶发病例，非常高的血浆浓度也与乳腺癌风险增加有关。在第三个队列中，主要是来自乳腺筛查项目的筛查检出病例，高血浆肠内酯浓度与乳腺癌风险的微弱降低相关。
Objective Using a nested case-referent design, we evaluated the relationship between plasma levels of the lignan enterolactone and the risk of developing breast cancer. Methods 248 cases and 492 referents were selected from three population-based cohorts in northern Sweden. Blood samples were donated at enrolment. All blood samples were stored at -80 degreesC. Cases and referents were matched for age, date of blood sample and sampling centre. Breast cancer cases were identified through the regional and national cancer registries. Results Plasma enterolactone was lower among smokers in all cohorts and in subjects with BMI < 23 and BMI > 28 in one of the cohorts. Low plasma concentrations of enterolactone, below the 12.5(th) percentile (mean plasma enterolactone 2.9 nmol/l), were associated with an increased risk of breast cancer. Also, high values of plasma enterolactone, above the 87.5(th) percentile (mean plasma enterolactone 58.2 nmol/l) were significantly associated with an increased breast cancer risk among women from two cohorts with only incident cases and a higher number of pre-menopausal women. High plasma enterolactone concentrations among older women from a mammary screening project with mostly prevalent cases were associated with a non-significant slightly reduced breast cancer risk. Conclusion Very low plasma concentrations of enterolactone were associated with an increased breast cancer risk in all three cohorts. In two of the cohorts, with only incident cases, very high plasma concentrations were also associated with an increased breast cancer risk. In the third cohort with mainly screen-detected cases from a mammary screening program, high plasma enterolactone concentrations were associated with a weak decreased breast cancer risk.