Human lymphocytes bear membrane receptors for C3b and C3d.
Human lymphocytes bear membrane receptors for C3b and C3d.
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人类淋巴细胞具有 C3b 和 C3d 的膜受体。
DOI：
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发表时间：
1973
影响因子：
15.9
通讯作者：
V. Nussenzweig
中科院分区：
文献类型：
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作者：
A. Eden;G. Miller;V. Nussenzweig
人外周血淋巴细胞具有 EAC43b（用抗体和补体致敏的绵羊红细胞）和 EAC43d（通过用 C3b 灭活剂处理 EAC43b 获得）的膜受体。人粒细胞仅结合 EAC43b，通过有限胰蛋白酶消化纯化的人 C3 获得的 C3 片段同时显示 C3b 和 C3d 位点，因为它们抑制淋巴细胞与 EAC43b 和 EAC43d 形成玫瑰花结。这些发现提出了这样一种可能性：C3b 和 C3d 受体位点可能选择性地分布在正常 B 淋巴细胞亚群以及白血病白细胞中。
Human peripheral blood lymphocytes have membrane receptors for EAC43b (sheep erythrocytes sensitized with antibody and complement) and also for EAC43d, obtained by treating EAC43b with C3b inactivator. Human granulocytes bind only EAC43b, C3 fragments obtained by limited trypsin digestion of purified human C3 display both C3b and C3d sites, since they inhibit rosette formation of lymphocytes with EAC43b and EAC43d. These findings raise the possibility that C3b and C3d receptor sites may be selectively distributed among normal subpopulations of B lymphocytes as well as among leukemic leukocytes.