TRAIL: a multifunctional cytokine
TRAIL: a multifunctional cytokine
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DOI：
10.2741/2354
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发表时间：
2007-05-01
期刊：
影响因子：
--
通讯作者：
Walczak, Henning
中科院分区：
文献类型：
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作者：
Schaefer, Uta;Voloshanenko, Oksana;Walczak, Henning
肿瘤坏死因子（tumor necrosis factor，TNF）相关凋亡诱导配体（tumor necrosis factor related apoptosis inducing Ligand，TRAIL）因其特异性抗肿瘤作用而受到广泛关注。TRAIL与复杂的受体系统结合。在人类中有两种TRAIL的死亡诱导受体，而在小鼠中只有一种。由这些受体诱导的信号传导导致细胞凋亡，但也可能导致存活信号的激活。为了评估基于TRAIL的癌症治疗的安全性和可能的副作用，有必要了解TRAIL/TRAIL-R系统的生理作用。这已经在缺乏TRAIL或其唯一的鼠凋亡诱导受体TRAIL-R（MK/mDR 5）的小鼠中得到解决。在这篇综述中，我们将讨论其表型和最近的研究结果的TRAIL在免疫系统的稳态中的作用，TRAIL/TRAIL-R系统对感染和自身免疫性疾病的影响和仍然有争议的作用，TRAIL在肿瘤发生。目前正在进行TRAIL和其他TRAIL受体激动剂的临床试验。这将是令人兴奋的，以确定哪些TRAIL-R激动剂，无论是单独或与其他抗癌治疗组合，将导致在未来的癌症治疗更好的结果。
The Tumor necrosis factor (TNF)-Related Apoptosis Inducing Ligand, TRAIL, has gained much attention due to its specific anti-tumor potential without toxic side effects. TRAIL binds to a complex receptor system. In humans there are two death-inducing receptors for TRAIL while only one is present in mice. The signaling induced by these receptors leads to apoptosis but might also result in activation of survival signals. To assess the safety and possible side effects of TRAIL-based cancer therapy it is necessary to understand the physiological role of the TRAIL/TRAIL-R system. This has been addressed in mice deficient either for TRAIL or for its only murine apoptosis- inducing receptor, TRAIL-R (MK/ mDR5). In this review we will discuss their phenotypes and the results of recent studies on the role of TRAIL in the homeostasis of the immune system, the influence of the TRAIL/TRAIL-R system on infection and autoimmune diseases and the still controversial role of TRAIL in tumorigenesis. Clinical trials with TRAIL and other TRAIL receptor agonists are now under way. It will be exciting to determine which TRAIL-R agonists, either alone or in combination with other anti-cancer therapeutics, will result in better outcome of cancer treatment in the future.