Optical glucose monitoring based on femtosecond two-color pulse interferometry
Optical glucose monitoring based on femtosecond two-color pulse interferometry
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DOI：
10.1007/s10043-006-0029-2
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发表时间：
2006-01-01
期刊：
影响因子：
1.2
通讯作者：
Araki, T
中科院分区：
文献类型：
--
作者：
Hori, Y;Yasui, T;Araki, T
我们证明了飞秒双色脉冲干涉术在体外光学葡萄糖监测的潜力，通过分散的葡萄糖溶液样品相对于红色光和蓝色光的群折射率。通过与飞秒单色脉冲干涉测量的比较，评价了本系统在灵敏度、定量性和对周围干扰的耐受性方面的基本性能。对于10 mm厚的样品，葡萄糖测定的准确度和精密度分别为77和118 mg/dl。双色脉冲光的这种近共光路配置为样品温度波动提供了良好的稳定性，这在临床应用中非常重要。考虑到飞秒双色脉冲干涉法在光学葡萄糖传感器中的性能，讨论了在体光学葡萄糖监测的合适测量位置。(c)2006日本光学学会
We demonstrate the potential of femtosecond two-color pulse interferometry for in vitro optical glucose monitoring, by dispersion of the group refractive index ill a glucose Solution sample with respect to a red-color light and a blue-color light. By comparison with femtosecond one-color pulse interferometry, the basic performance of the present system with regard to sensitivity, quantitativeness, and tolerance to surrounding disturbances, is evaluated. The resulting accuracy and precision of glucose determination are 77 and 118 mg/dl for 10-mm-sample-thickness, respectively. This near-common-path configuration of the two-color Pulse light provides good stability to fluctuations of sample temperature, which is important in clinical applications. Considering the performance of femtosecond two-color Pulse interferometry as in optical glucose sensor, a Suitable measurement site for in vivo Optical glucose monitoring is discussed. (c) 2006 The Optical Society of Japan