The Role of Cytokines in the Development of Atherosclerosis.
The Role of Cytokines in the Development of Atherosclerosis.
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DOI：
10.1134/s0006297916110134
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Koltsova EK
中科院分区：
文献类型：
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作者：
Fatkhullina AR;Peshkova IO;Koltsova EK
动脉粥样硬化导致许多心血管疾病的发展，这些疾病仍然是发达国家的主要死亡原因。动脉粥样硬化是一种大中型动脉的慢性炎症性疾病。它是由血脂异常引起的，由先天性和适应性免疫反应介导。炎症是动脉粥样硬化进展各个阶段的关键因素。参与动脉粥样硬化发病机制的细胞被可溶性因子、细胞因子激活，这些因子强烈影响疾病的发展。促炎细胞因子加速动脉粥样硬化的进展，而抗炎细胞因子改善疾病。本文就细胞因子在动脉粥样硬化发生发展中的作用作一综述。
Atherosclerosis contributes to the development of many cardiovascular diseases, which remain the leading cause of death in developed countries. Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries. It is caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a key factor at all stages of atherosclerosis progression. Cells involved in pathogenesis of atherosclerosis were shown to be activated by soluble factors, cytokines that strongly influence the disease development. Pro-inflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. In this review, we discuss the latest findings on the role of cytokines in the development and progression of atherosclerosis.