Recovery and relapse from major depressive disorder in the elderly.
Recovery and relapse from major depressive disorder in the elderly.
复制标题
老年人重度抑郁症的恢复和复发。
DOI：
10.1176/ajp.149.11.1575
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Hinrichsen,GA
中科院分区：
文献类型：
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作者：
Hinrichsen,GA
国家精神卫生研究所(NIMH)抑郁症心理生物学合作研究的结果引起了人们对年轻人严重抑郁障碍的长期预后的严重担忧。然而，很少有研究研究老年人严重抑郁障碍的预后，尽管有迹象表明，他们的临床结果比年轻人更差。本研究的目的是：1)记录一大批住院老年抑郁症患者的恢复率和复发率；2)比较NIMH合作研究中老年和混合年龄组患者的抑郁症恢复率和复发率。方法对127例符合Research诊断标准的老年住院患者进行为期1年的精神状态评估。NIMH研究采用相同的诊断和随访方法评估精神症状。结果入院一年后，72%的老年患者已经康复。然而，19%的康复患者随后发生了严重的抑郁障碍。老年人的恢复率和复发率与NIMH研究中混合年龄组的报告没有显著差异。结论单独指出老年人比其他人更有可能获得更差的纵向治疗结果是错误的。研究结果表明，需要继续改进对老年人的躯体和非躯体治疗，以提高抑郁症的持续恢复率。
ObjectiveResults from the National Institute of Mental Health (NIMH) Collaborative Study of the Psychobiology of Depression raised serious concerns about the longer-term prognosis for major depressive disorder in younger persons. However, little research has examined the prognosis for major depressive disorder in the elderly despite suggestions that they have poorer clinical outcomes than younger adults. The objective of this study was to 1) document rates of recovery and relapse from major depressive disorder in a large group of inpatient elderly and 2) compare recovery and relapse rates from major depressive disorder in the elderly with those in a mixed-age patient group from the NIMH collaborative study.MethodThe psychiatric status of 127 elderly inpatients diagnosed with major depressive disorder by Research Diagnostic Criteria was evaluated for 1 year. The same diagnostic and follow-up method to assess psychiatric symptoms employed in the NIMH study were used.ResultsOne year after study admission, 72% of elderly patients had recovered. Nineteen percent of recovered patients, however, had a subsequent episode of major depressive disorder. Recovery and relapse rates in the elderly did not significantly differ from those reported for the mixed-age group in the NIMH study.ConclusionsIt is erroneous to single out the elderly as being more likely to have poorer longitudinal treatment outcomes than others. Study findings indicate the need for continued refinement of somatic and nonsomatic treatments for the elderly to improve rates of sustained recovery from depression.