Design, synthesis, and diversification of 3,5-substituted enone library.
Design, synthesis, and diversification of 3,5-substituted enone library.
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3,5-取代烯酮文库的设计、合成和多样化。
DOI：
10.1021/co200070m
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发表时间：
2011
影响因子：
--
通讯作者：
Gilbertson,ScottR
中科院分区：
文献类型：
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作者：
Khalaf,Juhienah;Estrella-Jimenez,MariaE;Shashack,MatthewJ;Phatak,SharangdharS;Zhang,Shuxing;Gilbertson,ScottR
本文描述了300个成员的3，5-取代烯酮库的合成。合成从6种不同的溴烯酮开始，这些溴烯酮从相应的1，3二酮获得。这些溴化物然后通过与各种芳族和乙烯基硼酸的Suzuki偶联而多样化。此外，通过Sonogashira偶联反应偶极环加成序列合成了一系列三唑类化合物。采用主成分分析法对该文库进行分析，以考察其多样性。
This paper describes the synthesis of a 300 member library of 3,5-substituted enones. The synthesis starts with 6 different bromoenones that are accessed from the corresponding 1,3 diones. These bromides are then diversified by Suzuki coupling with a variety of aromatic and vinyl boronic acids. Additionally a small series of triazoles was synthesized by a Sonogashira coupling reaction dipolar cycloaddition sequence. The library was analyzed by principal component analysis to examine its diversity.