Low frequency repetitive transcranial magnetic stimulation improves source monitoring deficit in hallucinating patients with schizophrenia
Low frequency repetitive transcranial magnetic stimulation improves source monitoring deficit in hallucinating patients with schizophrenia
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DOI：
10.1016/j.schres.2005.10.009
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发表时间：
2006-01-01
影响因子：
4.5
通讯作者：
Saoud, M
中科院分区：
文献类型：
--
作者：
Brunelin, J;Poulet, E;Saoud, M
幻听与对自己言语的监控中断有关，这表明精神分裂症中的所有自主性失认症。这种缺陷需要通过源监测任务来测量。低频经颅磁刺激（rTMS）应用于左颞顶叶皮质呼叫抑制皮质区涉及自主性失认症（这意味着“无法识别自我产生的精神事件”）和病态幻听（AH）现象。尽管反复报道rTMS治疗后AH的改善，但从未研究过通过源监测测量的对自主性失认症的影响。我们的目的是调查rTMS治疗后AH和源监测性能的改善之间的关系。24例右利手难治性精神分裂症患者随机接受假或主动10.0001-Hz rTMS左颞顶皮层，并进行2个源监测任务，需要区分沉默和过度阅读的话之前和之后rTMS会议。与假手术相比，主动rTMS显著改善AH。源性监测的表现和改善倾向于相关，这将支持自主性失认症和幻听之间的特定关系。(c)2005 Elsevier B. V.保留所有权利。
Auditory hallucinations have been associated with a disruption in monitoring one's own speech suggesting all autonoetic agnosia in schizophrenia. This deficit call be measured by a Source monitoring task. Low frequency transcranial magnetic stimulations (rTMS) applied to the left temporoparietal cortex call inhibit cortical areas involved both in autonoetic agnosia (which means 'the inability to identify self-generated mental events') and ill auditory hallucinations (AH) phenomena. Although improvements in AH have been repeatedly reported following rTMS treatment, effects On autonoetic agnosia measured by source monitoring have never been investigated. We aimed to investigate the relation between improvements in AH and source monitoring performance after rTMS treatment. Twenty four right-handed refractory schizophrenic patients with hallucinations randomly received sham or active 10.0001-Hz rTMS to the left temporoparietal cortex and performed 2 source monitoring tasks requiring discrimination between silent- and overt-reading words before and after rTMS sessions. Compared to sham, active rTMS significantly improved AH. Source monitoring performances and the improvements tended to correlate, which Would Support a specific relation between autonoetic agnosia and auditory hallucinations. (c) 2005 Elsevier B.V. All rights reserved.