The role of toll-like receptors in macrophages
The role of toll-like receptors in macrophages
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DOI：
10.2741/2660
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发表时间：
2008-01-01
影响因子：
3.1
通讯作者：
O'Neill, Luke A. J.
中科院分区：
文献类型：
--
作者：
McCoy, Claire E.;O'Neill, Luke A. J.
巨噬细胞发挥多种作用，包括但不限于自我平衡清除、检测入侵病原体和诱导适应性免疫反应。自发现以来，人们已经清楚toll样受体（TLRs）可以在这些巨噬细胞功能中发挥重要作用。本文将对tlr及其信号通路及其在巨噬细胞功能中的作用进行综述。
Macrophages play diverse roles including but not limited to homeostatic clearance, detection of invading pathogens and induction of the adaptive immune response. Since their discovery, it has become clear that Toll-like receptors (TLRs) can play a major role in these macrophage functions. This review will describe the TLRs, their signalling pathways and their role in macrophage function.