DIFFERENTIAL SUSCEPTIBILITY OF 3 SUBLINES OF C57BL-6 MICE TO THE INDUCTION OF COLORECTAL TUMORS BY 1,2-DIMETHYL-HYDRAZINE
DIFFERENTIAL SUSCEPTIBILITY OF 3 SUBLINES OF C57BL-6 MICE TO THE INDUCTION OF COLORECTAL TUMORS BY 1,2-DIMETHYL-HYDRAZINE
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DOI：
10.1016/0304-3835(80)90114-7
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发表时间：
1980-01-01
期刊：
影响因子：
9.7
通讯作者：
BLACKMAN, KE
中科院分区：
文献类型：
--
作者：
DIWAN, BA;BLACKMAN, KE
对 C57BL/6 品系 3 个亚系的八周龄小鼠进行皮下注射。注射1,2-二甲基肼（DMH），每周一次，持续10周。 C57BL/6N 小鼠结直肠肿瘤的发病率最高（85%）。 43% 的 C57BL/6J 小鼠出现结直肠肿瘤，而只有 3 只 (10%) C57BL/6Ha 小鼠出现这些肿瘤。讨论了 C57BL/6 小鼠 3 个亚系对 DMH 诱导结直肠肿瘤的不同易感性的可能因素。
Eight week old mice of 3 sublines of strain C57BL/6 were given s.c. injections of 1,2-dimethylhydrazine (DMH), once weekly for 10 wk. The highest incidence (85%) of colorectal tumors occurred in C57BL/6N mice. Colorectal tumors occurred in 43% of C57BL/6J mice, while only 3 (10%) C57BL/6Ha mice developed these tumors. Possible factors responsible for the differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by DMH are discussed.