Clinical and biological significance of angiogenesis and lymphangiogenesis in colorectal cancer
Clinical and biological significance of angiogenesis and lymphangiogenesis in colorectal cancer
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DOI：
10.1016/j.dld.2008.07.315
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发表时间：
2009-02-01
影响因子：
4.5
通讯作者：
Sun, X. F.
中科院分区：
文献类型：
--
作者：
Gao, J.;Knutsen, A.;Sun, X. F.
背景。血管生成和淋巴管生成对肿瘤的发展和进展至关重要。然而，在结直肠癌（CRC）中，血管生成与临床预后之间的关系存在争议，由于缺乏淋巴管特异性标志物，淋巴管生成的预后意义尚未得到很好的研究。目的：按照国际上首次提出的血管密度评价标准方法和淋巴管密度评价血管密度，探讨其在慢性阻塞性肺疾病中的临床病理和生物学意义。采用CD31和D2-40抗体对原发肿瘤（2 10例）及其相邻正常粘膜（105例）和远处正常粘膜（27例）的MVD和LVD进行免疫组化检测。肿瘤组织的MVD和LVD均高于相应的正常粘膜。在肿瘤中，MVD与特别有趣的新半胱氨酸-组氨酸富蛋白（PINCH）表达呈正相关（P = 0.006），但与临床病理变量无关。肿瘤内和肿瘤周围的LVD与Dukes分期呈负相关。MVD和LVD与患者生存无相关性（P < 0.05）。血管生成和淋巴管生成发生在结直肠癌的发展过程中，但与结直肠癌患者的预后无关。PINCH可能在肿瘤血管生成中发挥潜在作用。(C) 2008年意大利胃肠病学编辑，爱思唯尔有限公司出版版权所有。
Background. Angiogenesis and lymphangiogenesis are essential for tumour development and progression. However, in colorectal cancer (CRC), the relationship between angiogenesis and clinical outcome is controversial, and the prognostic significance of lymphangiogenesis is not well examined because of the lack of specific a marker for lymphatic vessels.Aims. To evaluate blood microvessel density (MVD) following the proposed standard method for MVD assessment given by the first international consensus and lymphatic vessel density (LVD), and investigate their clinicopathologic and biologic significance in CRC.Methods. MVD and LVD in primary tumours (n = 2 10), along with their corresponding adjacent normal mucosa (n = 105) and distant normal mucosa (it = 27) specimens, were immunohistochemically examined by using CD31 and D2-40 antibodies.Results. Both MVD and LVD were higher in tumour compared with the corresponding normal mucosa. In tumours, MVD was positively related to particular interesting new cysteine-histidine-rich protein (PINCH) expression (P = 0.006), but not with clinicopathologic variables. LVD, in both intratumoural and peritumoural areas of tumours, was reversely related to Dukes' stage. There was no association between MVD or LVD and patients' survival (P > 0.05).Conclusions. Angiogenesis and lymphangiogenesis occurred in CRC development, but were not related to CRC patient prognosis. PINCH may play a potential role in tumour angiogenesis. (C) 2008 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.