Altered hydroxydesipramine concentrations in elderly depressed patients
Altered hydroxydesipramine concentrations in elderly depressed patients
复制标题
老年抑郁症患者羟基地昔帕明浓度的变化
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
W. Potter
中科院分区：
文献类型：
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作者：
I. Kitanaka;R. Ross;N. Cutler;A. Zavadil;W. Potter
最近的报道表明，地西帕明（DMI）的羟基代谢物具有药理活性，而不仅仅产生副作用。在接受DMI治疗的患者中，我们在稳定状态下测定了2 -羟基地西帕明（2 - OH - DMI）与药物的比例。老年患者的比例高于年轻患者，血浆2 - OH - DMI水平随着年龄的增长而增加，但尿清除率下降。已知肾小球滤过随着年龄的增长而减少，这可以解释2 - OH - DMI浓度在老年人中选择性增加的原因。
Recent reports demonstrate that hydroxy metabolites of desipramine (DMI) have pharmacologic activity and do not just produce side effects. In patients treated with DMI, we determined the ratio of 2‐hydroxydesipramine (2‐OH‐DMI) to drug at steady state. The ratios in the elderly patients were higher than in younger patients, and whereas plasma levels of 2‐OH‐DMI increased with age, urinary clearances decreased. The known decrease in glomerular filtration with age may explain the selective increase of 2‐OH‐DMI concentration in the elderly.