Poor Sleep Quality Linked to Decreased Brain Gray Matter Density in Adults with Type 2 Diabetes.
Poor Sleep Quality Linked to Decreased Brain Gray Matter Density in Adults with Type 2 Diabetes.
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睡眠质量差与成人 2 型糖尿病患者大脑灰质密度降低有关。
DOI：
10.1007/s41782-021-00170-4
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发表时间：
2021-12
影响因子：
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通讯作者：
Choi SE
中科院分区：
文献类型：
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作者：
Cabrera-Mino C;Roy B;Woo MA;Freeby MJ;Kumar R;Choi SE
2型糖尿病（T2DM）患者的睡眠质量差是常见的，这可能会导致脑组织的变化。然而，睡眠质量对T2DM患者脑组织的影响尚不清楚。我们的目的是评估不同的睡眠质量与大脑的变化，脑组织的完整性在T2DM患者。数据收集自34例T2DM患者，包括睡眠质量（通过匹兹堡睡眠质量指数[PSQI]评估）和使用3.0特斯拉MRI扫描仪的高分辨率T1加权脑图像。通过PSQI（协变量：年龄、性别、BMI）评估，比较睡眠质量好与差的受试者之间的灰质密度（GMD）图。34例T2DM患者中，17例睡眠质量差。睡眠质量差的T2DM患者的多个大脑部位（包括海马、小脑、前额叶、杏仁核、丘脑、下丘脑、小脑、扣带回和颞叶）的灰质比睡眠质量好的患者减少。PSQI评分与多个区域的灰质密度呈负相关。睡眠质量差的2型糖尿病患者在睡眠调节相关部位表现出脑组织改变。研究结果表明，改善睡眠可能有助于减轻脑组织损伤，从而改善T2DM患者的脑功能。
Poor sleep is common in adults with Type 2 Diabetes Mellitus (T2DM), which may contribute to brain tissue changes. However, the impact of sleep quality on brain tissue in T2DM individuals is unclear. We aimed to evaluate differential sleep quality with brain changes, and brain tissue integrity in T2DM patients. Data were collected from 34 patients with T2DM and included sleep quality (assessed by the Pittsburgh Sleep Quality Index [PSQI], and high-resolution T1-weighted brain images using a 3.0-Tesla MRI scanner. Gray matter density (GMD) maps were compared between subjects with good vs poor sleep quality as assessed by PSQI (covariates: age, sex, BMI). Of 34 T2DM patients, 17 showed poor sleep quality. Multiple brain sites, including the hippocampus, cerebellum, prefrontal, amygdala, thalamus, hypothalamus, insula, cingulate, and temporal areas, showed reduced gray matter in T2DM patients with poor sleep quality over patients with good sleep quality. Negative associations emerged between PSQI scores and gray matter density in multiple areas. T2DM patients with poor sleep quality show brain tissue changes in sites involved in sleep regulation. Findings indicate that improving sleep may help mitigate brain tissue damage, and thus, improve brain function in T2DM patients.