Melatonin MT-1-receptor immunoreactivity in the human eye
Melatonin MT-1-receptor immunoreactivity in the human eye
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DOI：
10.1136/bjo.86.9.1053
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发表时间：
2002-09-01
影响因子：
4.1
通讯作者：
Savaskan, E
中科院分区：
文献类型：
--
作者：
Meyer, P;Pache, M;Savaskan, E
目的：检测褪黑素1a(MT1)受体在人眼组织中的分布。方法：采用免疫组织化学方法对7只正常人眼组织进行MT1受体免疫组织化学染色。结果：MT1受体免疫反应性(MT1-IR)主要分布在视杆细胞和视锥细胞的内段及视网膜神经节细胞中。此外，MT1-IR存在于视网膜动脉和静脉的外膜，包括乳头区，但在睫状血管和脉络膜血管中不存在。除2只眼外，其余眼均可见角膜内皮细胞和角质形成细胞轻度染色。结论：MT1-IR在各种眼组织中均有表达，以感光细胞和神经节细胞密度最高。这些受体的生理功能值得进一步研究。
Aim: To examine the distribution of melatonin 1 a (MT1) receptors in the human eye.Methods: Seven normal human eyes were examined by immunohistochemical staining of paraffin sections, using an anti-MT1 primary antibody and an ABC detection system.Results: MT1 receptor immunoreactivity (MT1-IR) was detected primarily in the inner segments of rods and cones and in retinal ganglion cells. In addition, MT1-IR was present in the adventitia of retinal arteries and veins, including the papillary region, but absent in ciliary and choroidal vessels. Mild staining of corneal endothelial cells and keratocytes was observed in all but two eyes.Conclusion: MT1-IR is present in various ocular tissues with the highest density in photoreceptor cells and ganglion cells. The physiological function of these receptors deserves further investigation.