An adaptive-coherence light source for hyperspectral, topographic, and flow-contrast imaging.
An adaptive-coherence light source for hyperspectral, topographic, and flow-contrast imaging.
复制标题
用于高光谱、地形和血流对比成像的自适应相干光源。
DOI：
10.1117/12.2510632
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Durr,NicholasJ
中科院分区：
文献类型：
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作者：
Bobrow,TaylorL;Durr,NicholasJ
据估计，结直肠癌占美国癌症死亡的8%，五年生存率为55%-75%。早期发现和切除癌前病变是降低死亡率的关键，但细微的肿瘤生长，如非息肉样病变，在常规结肠镜检查中往往没有被发现。目前检测扁平或凹陷病变的方法是无效的，因为白光内窥镜的细微特征对比度较差。为了提高结直肠病变的对比度，我们提出了一种具有定制激光通道的内窥镜光源，用于多模彩色、地形和散斑对比度血流成像。三个红绿蓝激光单元与激光散斑消除器配对，耦合到台式内窥镜的内窥镜光纤光导中。使用激光单元的交替照明和光度立体内窥镜算法重建组织模型地形。使用激光散斑对比成像来增强光流体模中流动区域的对比度。此外，该系统保留了提供白光和窄带照明模式的能力，与传统的内窥镜弧灯光源相比，该模式具有更高的功率效率、更小的尺寸和更长的寿命。这一新的内窥镜光源设计显示出在常规结肠镜筛查中提高微小病变检测的前景。
Colorectal cancer accounts for an estimated 8% of cancer deaths in the United States with a five-year survival rate of 55-75%. The early detection and removal of precancerous lesions is critical for reducing mortality, but subtle neoplastic growths, such as non-polypoid lesions, often go undetected during routine colonoscopy. Current approaches to flat or depressed lesion detection are ineffective due to the poor contrast of subtle features in white light endoscopy. Towards improving colorectal lesion contrast, we present an endoscopic light source with custom laser channels for multimodal color, topographic, and speckle contrast flow imaging. Three red-green-blue laser units, paired with laser speckle reducers, are coupled into endoscopic fiber optic light guides in a benchtop endoscope. Tissue phantom topography is reconstructed using alternating illumination of the laser units and a photometric stereo endoscopy algorithm. The contrast of flow regions is enhanced in an optical flow phantom using laser speckle contrast imaging. Further, the system retains the ability to offer white light and narrow band illumination modes with improved power efficiency, a reduced size, and longer lifetimes compared to conventional endoscopic arc lamp sources. This novel endoscopic light source design shows promise for increasing the detection of subtle lesions in routine colonoscopy screening.