EFFECT OF RELAXIN ON MAMMARY DEVELOPMENT IN OVARIECTOMIZED PREGNANT GILTS
EFFECT OF RELAXIN ON MAMMARY DEVELOPMENT IN OVARIECTOMIZED PREGNANT GILTS
复制标题
DOI：
10.1210/endo-128-3-1285
复制
发表时间：
1991-03-01
期刊：
影响因子：
4.8
通讯作者：
SHERWOOD, OD
中科院分区：
文献类型：
--
作者：
HURLEY, WL;DOANE, RM;SHERWOOD, OD
在妊娠80-110天之间，研究了松弛素在切除卵巢的小母猪中乳房发育中的作用，这些母猪给予孕酮以维持妊娠。为了获得小叶-肺泡（实质）组成的客观测量值，通过乳头切割乳腺的横截面，并确定腺体暴露面上的实质组织面积。卵巢切除术后第80天或100天孕激素替代治疗导致显着减少的增长率乳腺实质横截面积在妊娠第100天和110天，分别与对照组相比。相反，黄体酮加松弛素治疗，高度纯化的猪松弛素，恢复乳腺实质横截面积的控制值在卵巢切除后备母猪。妊娠第110天乳腺组织的形态测定分析表明，卵巢切除术后松弛素的缺乏和卵巢切除后备母猪中猪松弛素的替代治疗对构成乳腺实质的管腔、基质或上皮细胞的百分比几乎没有影响。结论：松弛素对妊娠后期猪乳腺实质组织的生长具有促进作用。
The role of relaxin in mammary development was studied between days 80-110 of pregnancy in ovariectomized gilts given progesterone to maintain pregnancy. To obtain an objective measurement of lobulo-alveolar (parenchymal) composition, mammary glands were cut in cross-section through the teat, and the area of parenchymal tissue on the exposed face of the gland was determined. Ovariectomy on day 80 or 100 followed by progesterone replacement therapy resulted in a dramatic reduction in the rate of growth of mammary parenchymal cross-section area on days 100 and 110 of gestation, respectively, compared to that in controls. In contrast, progesterone plus relaxin therapy, with highly purified porcine relaxin, restored the mammary parenchymal cross-section area to control values in ovariectomized gilts. Morphometric analysis of mammary tissue on day 110 of pregnancy indicated that both the absence of relaxin after ovariectomy and replacement therapy with porcine relaxin in ovariectomized gilts had little if any effect on the percentages of the lumen, stroma, or epithelia that comprised the mammary parenchyma. It is concluded that relaxin has a stimulatory effect on the growth of mammary parenchymal tissue during late gestation in the pig.