Arterial stiffness as a risk factor for coronary atherosclerosis.
Arterial stiffness as a risk factor for coronary atherosclerosis.
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DOI：
10.1007/s11883-007-0010-y
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发表时间：
2007-08-01
影响因子：
5.8
通讯作者：
Cohn, Jay N
中科院分区：
文献类型：
--
作者：
Duprez, Daniel A;Cohn, Jay N
冠状动脉粥样硬化的主要病理生理过程是动脉内皮功能的缺陷或损伤。冠状动脉粥样硬化的进展速度是高度可变的，主要由风险因素如脂质、葡萄糖和吸烟决定。冠状动脉斑块破裂是血栓形成和急性冠状动脉事件的促发因素。用不同的非侵入性技术测量动脉硬度提供了关于主动脉、肌性导管动脉、外周分支和微血管成分水平的功能和结构血管变化的信息。动脉僵硬度与心率和其他心血管风险评分相关。大动脉僵硬度与冠心病患者运动诱发的心肌缺血有关。它可以预测冠状动脉介入治疗后的结果。现在有证据表明，动脉硬度是一般人群中心血管事件的预测因子，包括高血压、终末期肾病、糖耐量异常和冠状动脉疾病患者。未来的研究有必要证明随访动脉僵硬度作为降压、降糖和降脂治疗期间动脉壁损伤减少的标志物的价值。有希望的研究结果表明，动脉硬度的测量可以成为日常实践中对患者进行常规评估的重要组成部分。
The major pathophysiologic process of coronary atherosclerosis is a defect or injury of the arterial endothelial function. The rate of progression of coronary atherosclerosis is highly variable and mainly determined by risk contributors such as lipids, glucose, and smoking. Coronary plaque rupture is the precipitating factor for clot formation and acute coronary events. Measurement of arterial stiffness with different noninvasive techniques provides information about the functional and structural vascular changes at the level of the aorta, muscular conduit arteries, the peripheral branches, and the microvascular components. Arterial stiffness has been related to the Framingham and other cardiovascular risk scores. Large artery stiffness contributes to exercise-induced myocardial ischemia in patients with coronary artery disease. It can predict the outcome after coronary interventions. There is now evidence that arterial stiffness is a predictor for cardiovascular events in the general population, in patients with hypertension, end-stage renal disease, impaired glucose intolerance, and coronary artery disease. Future studies are warranted to demonstrate the value of follow-up of arterial stiffness as a marker of reduction of arterial wall damage during antihypertensive, antidiabetic, and lipid-lowering therapy. Promising study results show that measurement of arterial stiffness could become an important part of the routine assessment of patients in daily practice.