Modulation of HIV transmission by Neisseria gonorrhoeae: molecular and immunological aspects.
Modulation of HIV transmission by Neisseria gonorrhoeae: molecular and immunological aspects.
复制标题
DOI：
10.2174/157016212800618138
复制
发表时间：
2012-04
影响因子：
1
通讯作者：
Chang TL
中科院分区：
文献类型：
--
作者：
Jarvis GA;Chang TL
Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in monocytes and modulate T cell activation. In vivo, an increase in the number of endocervical CD4+ T cells has been found in GC-infected women. Additionally, GC appears to modulate HIV-specific immune responses in HIV-exposed sex workers. Interestingly, in vitro, GC exhibits HIV enhancing or inhibitory effects depending on the HIV target cells. This review summarizes molecular and immunological aspects of the modulation of HIV infection and transmission by GC. Future studies using a multi-cellular system or in animal models will offer insight into the mechanisms by which GC increases HIV transmission.
