Anti-microbial activities of mannose-binding lectin
Anti-microbial activities of mannose-binding lectin
复制标题
甘露糖结合凝集素的抗微生物活性
DOI：
10.1042/bst0310753
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发表时间：
2003-08-01
影响因子：
3.9
通讯作者：
Turner, MW
中科院分区：
文献类型：
--
作者：
Jack, DL;Turner, MW
甘露糖结合凝集素（MBL;也称为甘露聚糖结合凝集素）通过模式识别检测模式与细菌、病毒、原生动物和蠕虫结合，然后引发一系列宿主反应，参与第一线防御。目前，我们已经无法从我们所知道的MBL结合的生物化学来推断准确地预测MBL与单个微生物的相互作用;即使是细微的表面改变也已被证明对MBL介导的病原体识别具有广泛的影响。MBL通过MBL相关的丝氨酸蛋白酶（MASP）激活补体系统而具有主要的保护作用。这可以引起革兰氏阴性菌的溶解，并且还调理广泛的潜在病原体以进行吞噬。MBL还可以通过与一种或多种凝集素受体的相互作用在不存在补体活化的情况下影响吞噬作用。这也可能是蛋白质对炎症反应的直接影响的基础。MBL可以改变微生物结构的功能，如HIV的gp 120，以防止感染。该蛋白质还可以与其他级联系统的组分相互作用，例如凝血系统，这将在微生物发病机制中发挥作用。了解这些基本机制将是至关重要的，如果我们要使用纯化或重组MBL的治疗应用。
Mannose-binding lectin (MBL; also known as mannan-binding lectin) is involved in first-line defence by binding to bacteria, viruses, protozoa and helminths through a pattern-recognition mode of detection and then initiating a range of host responses. Currently, we have been unable to extrapolate from what we know of the biochemistry of MBL binding to predict accurately the interaction of MBL with individual microorganisms; even subtle surface alterations have been shown to have an extensive impact on MBL-mediated recognition of pathogens. MBL has a major protective effect through activation of the complement system via MBL-associated serine proteases (MASPs). This can cause the lysis of Gram-negative bacteria and also opsonize a wide spectrum of potential pathogens for phagocytosis. MBL may also influence phagocytosis in the absence of complement activation through an interaction with one or more collectin receptors. This may also be the basis for a direct effect of the protein on inflammatory responses. MBL can alter the function of microbial structures, such as gp120 of HIV, to prevent infection. The protein may also interact with the components of other cascade systems such as the clotting system, which will have a role in microbial pathogenesis. An understanding of these basic mechanisms will be vital if we are to use purified or recombinant MBL in therapeutic applications.