Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 mRNA expression in ectopic and eutopic endometrium in women with endometriosis: a rationale for endometriotic invasiveness
Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 mRNA expression in ectopic and eutopic endometrium in women with endometriosis: a rationale for endometriotic invasiveness
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DOI：
10.1016/s0015-0282(00)01670-8
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发表时间：
2001-01-01
影响因子：
6.7
通讯作者：
Polan, ML
中科院分区：
文献类型：
--
作者：
Chung, HW;Wen, Y;Polan, ML
目的：目的：探讨金属蛋白酶-9（MMP-9）和金属蛋白酶组织抑制剂-3（TIMP-3）在异位子宫内膜异位症组织和子宫内膜中的mRNA表达。53名绝经前妇女（23名子宫内膜异位症妇女和30名接受腹腔镜手术的非子宫内膜异位症妇女）。在手术时获取子宫内膜和异位内膜组织。干预：无。主要观察指标：通过定量竞争PCR分析在位和异位内膜的mRNA表达。结果：子宫内膜异位症患者的子宫内膜和异位内膜组织均表达显著（P
Objective: To investigate mRNA expression of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-3 (TIMP-3) in ectopic endometriosis tissue and uterine endometrium from women with and without endometriosis throughout the menstrual cycle.Design: Molecular studies in human tissue.Setting: Department of Gynecology and Obstetrics, Reproductive Immunology Laboratory, Stanford University Medical Center.Patient(s): Fifty-three premenopausal woman (23 women with endometriosis and 30 women without endometriosis undergoing laparoscopic surgery). Endometrium and ectopic endometriosis tissue were obtained at the time of surgery.Intervention(s): None.Main Outcome Measure(s): mRNA expression from eutopic and ectopic endometrium was analyzed by quantitative, competitive PCR.Result(s): Both uterine endometrium and ectopic endometriotic tissue from women with endometriosis expressed significantly (P