Alterations in affective behavior during the time course of alcohol hangover
Alterations in affective behavior during the time course of alcohol hangover
复制标题
DOI：
10.1016/j.bbr.2013.07.011
复制
发表时间：
2013-09-15
影响因子：
2.7
通讯作者：
Cutrera, Rodolfo A.
中科院分区：
文献类型：
--
作者：
Karadayian, Analia G.;Busso, Maria J.;Cutrera, Rodolfo A.
酒精宿醉是一种暂时的状态，被描述为在类似狂欢的饮酒后第二天产生的不愉快的影响。当血浆中没有酒精时，宿醉就会开始，并以身体和心理症状为特征。在酒精中毒的急性期，情感行为受到损害；然而，没有报告表明在戒酒期间是否观察到类似的影响。这项工作的目的是研究宿醉发作期间情感行为的时间延长和可能的波动。雄性瑞士小鼠ip。给予生理盐水(对照组)或乙醇(3.8g/kg体重)(宿醉组)。焦虑、恐惧相关行为和绝望表型在一个基点(ZT0)和每隔2小时至20小时的血液酒精水平接近于零(宿醉开始)时进行评估。此外，还研究了快感缺失体征和疼痛感知障碍。分别进行高架迷宫和旷场测试时，小鼠在宿醉后4h和14h表现出焦虑样行为增加(p<；0.05)。在宿醉开始后的16小时内，宿醉动物的恐惧相关行为表现为结冰增加，穿越线路和饲养频率减少(p<；0.001)。宿醉小鼠在14h内出现抑郁症状(p<；0.05)。在宿醉开始时，通过浸尾测试，宿醉小鼠的痛觉显著降低(p<；0.05)。我们的发现表明，宿醉情感障碍的时间延长了14到16小时。这项研究显示了在酒精中毒阶段宿醉的长期影响。(C)2013爱思唯尔B.V.保留所有权利。
Alcohol hangover is a temporary state described as the unpleasant next-day effects after binge-like drinking. Hangover begins when ethanol is absent in plasma and is characterized by physical and psychological symptoms. Affective behavior is impaired during the acute phase of alcohol intoxication; however, no reports indicate if similar effects are observed during withdrawal. The aim of this work was to study the time-extension and possible fluctuations in affective behavior during a hangover episode. Male Swiss mice were injected i.p. either with saline (control group) or with ethanol (3.8 g/kg BW) (hangover group). Anxiety, fear-related behavior and despair phenotype were evaluated at a basal point (ZT0) and every 2 h up to 20 h after blood alcohol levels were close to zero (hangover onset). Also, anhedonia signs and pain perception disabilities were studied. Mice exhibited an increase in anxiety-like behavior during 4 h and 14h after hangover onset when evaluated by the elevated-plus maze and open field test respectively (p < 0.05). Fear-related behavior was detected in hangover animals by the increase of freezing and decrease of line crossings and rearing frequency during 16 h after hangover onset (p < 0.001). Depression signs were found in hangover mice during 14 h (p < 0.05). Hangover mice showed a significant decrease in pain perception when tested by tail immersion test at the beginning of hangover (p < 0.05). Our findings demonstrate a time-extension between 14 and 16 h for hangover affective impairments. This study shows the long lasting effects of hangover over the phase of ethanol intoxication. (C) 2013 Elsevier B.V. All rights reserved.