In Vivo Efficacy of β-Cyclodextrin Derivatives against Anthrax Lethal Toxin
In Vivo Efficacy of β-Cyclodextrin Derivatives against Anthrax Lethal Toxin
复制标题
β-环糊精衍生物抗炭疽致死毒素的体内功效
DOI：
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发表时间：
2008
影响因子：
4.9
通讯作者：
V. Karginov
中科院分区：
文献类型：
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作者：
M. Moayeri;Tanisha M. Robinson;S. Leppla;V. Karginov
摘要我们评价了三种β-环糊精衍生物对炭疽保护性抗原孔的体内阻断效果。在大鼠模型中，这些化合物在保护免受炭疽致死毒素方面的效力比先前描述的β-环糊精强至少15倍。其中一种药物被证明可以保护小鼠免受细菌感染。
ABSTRACT We evaluated the in vivo efficacy of three β-cyclodextrin derivatives that block the anthrax protective antigen pore. These compounds were at least 15-fold more potent than previously described β-cyclodextrins in protecting against anthrax lethal toxin in a rat model. One of the drugs was shown to protect mice from bacterial infection.
影响因子：
6
作者：
Firoved, AM;Miller, GF;Leppla, SH
通讯作者：
Leppla, SH