SERUM OSTEOCALCIN AND VITAMIN-D METABOLITES IN PATIENTS WITH ANKYLOSING-SPONDYLITIS
SERUM OSTEOCALCIN AND VITAMIN-D METABOLITES IN PATIENTS WITH ANKYLOSING-SPONDYLITIS
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DOI：
10.1136/ard.52.5.343
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发表时间：
1993-05-01
影响因子：
27.4
通讯作者：
KECK, E
中科院分区：
文献类型：
--
作者：
FRANCK, H;KECK, E
目的：骨钙素是骨的主要非胶原蛋白，被认为是骨形成的特异性指标。方法测定38例强直性脊柱炎(AS)患者和52例正常对照的血清骨钙素、碱性磷酸酶、甲状旁腺激素和1，25-二羟基维生素D。结果强直性脊柱炎患者血清骨钙素水平(男性1.7(1.1)ng/ml；女性1.2(1-1)ng/ml)显著低于相应对照组(男性3.2(1.3)ng/ml；女性4.1(1.7)ng/ml)。而AS患者血清碱性磷酸酶仅略高于对照组(135(44)U/L)，显著高于对照组(114(35)U/L)。AS患者血清甲状旁腺激素(AS 3.1(0.7)vs 2.7(0.6)Me/ml)和1，25-二羟基维生素D(AS 64.0(34.S)vs S2.4(6.7)pg/ml)略高，但差异无统计学意义。因此，由于这两种激素都能刺激骨钙素的合成，它们不是AS患者骨钙素水平低的原因。碱性磷酸酶与骨钙素无明显相关性。AS患者血清骨钙素水平降低反映AS成骨细胞活性降低。结论：在钙调节激素水平正常的情况下，AS患者的骨转换以骨形成减少为特征。
Objectives-Osteocalcin is the major non-collagenous protein of bone and is regarded as a specific index of bone formation. The aim of this study was to examine the rate of bone formation measured by osteocalcin in 38 patients with ankylosing spondylitis (AS) and its dependence on various parameters of calcium and phosphate metabolism.Methods-Serum osteocalcin, alkaline phosphatase, parathyroid hormone, and 1,25-dihydroxyvitamin D were measured in 38 patients with ankylosing spondylitis and in 52 controls.Results-Mean serum osteocalcin was significantly reduced in patients with AS (men 1.7 (1.1) ng/ml; women 1.2 (1-1) ng/ml) compared with the corresponding control groups (men 3.2 (1.3) ng/ml; women 4.1 (1.7) ng/ml). In contrast, alkaline phosphatase was only slightly but significantly higher (135 (44) U/l) in patients with AS than in the corresponding controls (114 (35) U/l). Serum parathyroid hormone (AS 3.1 (0.7) v 2.7 (0.6) mE/ml) and 1,25-dihydroxyvitamin D (AS 64.0 (34.S) v S2.4 (6.7) pg/ml) were slightly but not significantly higher in patients with AS. Consequently, as both hormones are known to stimulate osteocalcin synthesis, they are not responsible for low osteocalcin levels in patients with AS. No significant correlation between alkaline phosphatase and osteocalcin was found. Low serum levels of osteocalcin in patients with AS reflect lower osteoblastic activity in AS.Conclusions-Bone turnover in patients with AS is characterised by low bone formation in the presence of normal levels of calcium regulating hormones.