The role of circulating fibrocytes in fibrosis.
The role of circulating fibrocytes in fibrosis.
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DOI：
10.1007/s11926-006-0055-x
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发表时间：
2006-04-01
影响因子：
5
通讯作者：
Bucala, Richard
中科院分区：
文献类型：
--
作者：
Quan, Timothy E;Cowper, Shawn E;Bucala, Richard
纤维细胞是在外周血中循环的细胞，产生结缔组织蛋白，如波形蛋白和胶原I和III。纤维细胞与皮肤病变、肺纤维化和肿瘤有关，它们通过分泌基质金属蛋白酶参与重塑反应。纤维细胞可以进一步分化，它们是许多纤维化病变中出现的可收缩肌成纤维细胞的可能来源。有证据表明，皮肤纤维细胞在肥厚性疤痕和瘢痕疙瘩的发展中起着突出的作用。在哮喘或肺纤维化的实验模型中，纤维细胞已被证明浸润炎症和组织损伤区域。纤维细胞构成对肿瘤侵袭的间质反应的一部分，有证据表明这些细胞可能是恶性潜能的预后因子。IL-1、tgf - β、趋化因子和血清淀粉样蛋白P调节纤维细胞的外观和功能。纤维细胞本身产生炎症细胞因子、生长因子和趋化因子。调节纤维细胞运输、增殖和分化的细胞间信号仅被部分定义，但对这些信号的更好理解使新疗法能够预防病理性纤维化或改善组织修复反应。
Fibrocytes are cells that circulate in the peripheral blood and produce connective tissue proteins such as vimentin and collagens I and III. Fibrocytes are associated with skin lesions, pulmonary fibrosis, and tumors and they contribute to the remodeling response by secreting matrix metalloproteinases. Fibrocytes can further differentiate, and they are a likely source of the contractile myofibroblast that appears in many fibrotic lesions. There is evidence in the skin for a prominent role for fibrocytes in the development of hypertrophic scars and keloids. In asthma or in experimental models of pulmonary fibrosis, fibrocytes have been shown to infiltrate areas of inflammation and tissue damage. Fibrocytes constitute part of the stromal response to tumor invasion, and there is evidence that these cells may be a prognosticator of malignant potential. IL-1, TGF-beta, chemokines, and serum amyloid P modulate the appearance and function of fibrocytes. Fibrocytes themselves produce inflammatory cytokines, growth factors, and chemokines. The intercellular signals that modulate fibrocyte trafficking, proliferation, and differentiation are only partially defined, but a better understanding of these signals enable new therapies to prevent pathologic fibrosis or to improve the tissue repair response.