Cellular volume homeostasis
Cellular volume homeostasis
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DOI：
10.1152/advan.00034.2004
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发表时间：
2004-12-01
影响因子：
2.1
通讯作者：
Strange, K
中科院分区：
文献类型：
--
作者：
Strange, K
所有细胞都面临着不断的挑战，无论是通过细胞内溶质含量或细胞外渗透压的变化，其体积。细胞通过激活膜转运和/或代谢过程来响应体积扰动，导致净溶质损失或增加，并使细胞体积恢复到其正常静息状态。本文简要介绍了渗透水跨膜流动的基本概念、细胞体积扰动的机制、无机离子和有机渗透调节剂在细胞体积调节中的作用以及调节细胞体积敏感性运输和代谢途径活性的信号机制。
All cells face constant challenges to their volume either through changes in intracellular solute content or extracellular osmolality. Cells respond to volume perturbations by activating membrane transport and/or metabolic processes that result in net solute loss or gain and return of cell volume to its normal resting state. This paper provides a brief overview of fundamental concepts of osmotic water flow across cell membranes, mechanisms of cell volume perturbation, the role of inorganic ions and organic osmolytes in cell volume regulation and the signaling mechanisms that regulate the activity of cell volume-sensitive transport and metabolic pathways.