Spinal cord injury immediately decreases anesthetic requirements in rats
Spinal cord injury immediately decreases anesthetic requirements in rats
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DOI：
10.1038/sc.2011.11
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发表时间：
2011-07-01
期刊：
影响因子：
2.2
通讯作者：
Aguilar, J.
中科院分区：
文献类型：
--
作者：
Foffani, G.;Humanes-Valera, D.;Aguilar, J.
研究设计：药物阻断脊髓可产生镇静作用，减少患者和动物的麻醉需求。脊髓损伤是否也减少了麻醉需求仍不清楚。方法：回顾性分析经尿素麻醉的大鼠15的数据，以评估脊髓全胸横断术后立即的麻醉需求。脊髓横断后12小时，通过对有害刺激的反射和初级体感觉皮层的小管下层的电生理记录来监测麻醉深度。每当动物表现出电生理和/或行为激活迹象时，我们就给予额外剂量的麻醉。将接受脊髓横断的动物（n = 11）与接受“假”损伤的对照动物（n = 9）的麻醉需求进行比较。结果：与对照动物相比，横切动物维持稳定麻醉水平所需的累积剂量明显降低。脊髓损伤后约7小时，平均累积剂量仅为原始剂量的1.13 +/- 0.14，而对照组为原始剂量的1.64 +/- 0.19。结论：脊髓横断可立即降低大鼠的麻醉需求。为了确定这些结果是否与脊髓损伤患者相关，还需要进一步的研究。脊髓（2011）49,822-826；doi: 10.1038 / sc.2011.11;2011年3月1日在线发布
Study design: Pharmacologically blocking the spinal cord produces sedative effects and reduces anesthesia requirements in patients and animals. Whether spinal cord injury also reduces anesthesia requirements remains unclear.Methods: We retrospectively analyzed data from urethane-anesthetized rats 15 to assess anesthesia requirements immediately after complete thoracic transection of the spinal cord. The depth of anesthesia was monitored up to 12 h after spinal transection by the reflexes to noxious stimuli and by electrophysiological recordings from the infragranular layers of the primary somatosensory cortex. Whenever animals displayed electrophysiological and/or behavioral signs of activation, we delivered an additional dose of anesthesia. Anesthetic requirements in animals receiving spinal transection (n = 11) were compared with control animals receiving 'sham' lesion (n = 9).Results: The cumulative dose necessary to maintain a stable level of anesthesia was significantly lower in transected animals compared with control animals. By about 7 h after spinal cord injury, on average the cumulative dose of urethane was only 1.13 +/- 0.14 of the original dose, compared with 1.64 +/- 0.19 of the original dose in control animals.Conclusions: Spinal transection immediately decreased anesthetic requirements in rats. To establish whether these results are relevant for patients with spinal cord injury will require further investigation. Spinal Cord (2011) 49, 822-826; doi: 10.1038/sc.2011.11; published online 1 March 2011