Akirin: a context-dependent link between transcription and chromatin remodeling.
Akirin: a context-dependent link between transcription and chromatin remodeling.
复制标题
DOI：
10.4161/bioa.22907
复制
发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Baylies MK
中科院分区：
文献类型：
--
作者：
Nowak SJ;Baylies MK
胚胎模式依赖于一个精确定时的基因调控程序。虽然通过转录因子网络的作用对这一过程的调节已经被很好地理解，但新的研究路线强调了在发育过程中同时调节染色质重塑的重要性。染色质重塑是指通过核小体的重排、重新定位或重组来操纵染色质结构，以利于或阻碍相关基因的表达。虽然染色质重塑通路在肿瘤发生和发展过程中的作用开始被阐明，但这些通路在组织特化、形态发生和图案化过程中的作用仍然相对未知。此外，对发育关键转录因子与染色质重塑因子协调以优化基因表达的靶基因位点的机制了解相对较少。这种机制可能涉及直接的转录因子/染色质重塑因子的相互作用，也可能通过未知的中介调节。我们的团队已经确定相对未知的Akirin蛋白是后一类蛋白的假定成员：一种次级辅助因子，作为发育关键转录因子和染色质重塑机制之间的接口。Akirin蛋白的这种作用表明了一种新的调控模式，用于调节发育过程中的基因表达。
Embryonic patterning relies upon an exquisitely timed program of gene regulation. While the regulation of this process via the action of transcription factor networks is well understood, new lines of study have highlighted the importance of a concurrently regulated program of chromatin remodeling during development. Chromatin remodeling refers to the manipulation of the chromatin architecture through rearrangement, repositioning, or restructuring of nucleosomes to either favor or hinder the expression of associated genes. While the role of chromatin remodeling pathways during tumor development and cancer progression are beginning to be clarified, the roles of these pathways in the course of tissue specification, morphogenesis and patterning remains relatively unknown. Further, relatively little is understood as to the mechanism whereby developmentally critical transcription factors coordinate with chromatin remodeling factors to optimize target gene loci for gene expression. Such a mechanism might involve direct transcription factor/chromatin remodeling factor interactions, or could likely be mediated via an unknown intermediary. Our group has identified the relatively unknown protein Akirin as a putative member of this latter group: a secondary cofactor that serves as an interface between a developmentally critical transcription factor and the chromatin remodeling machinery. This role for the Akirin protein suggests a novel regulatory mode for regulating gene expression during development.