Anti-aging and redox state regulation effects of A-type proanthocyanidins-rich cranberry concentrate and its comparison with grape seed extract in mice
Anti-aging and redox state regulation effects of A-type proanthocyanidins-rich cranberry concentrate and its comparison with grape seed extract in mice
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富含A型原花青素的蔓越莓浓缩物的抗衰老和氧化还原态调节作用及其与葡萄籽提取物对小鼠的比较
DOI：
10.1016/j.jff.2016.12.039
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发表时间：
2017-03-01
影响因子：
5.6
通讯作者：
Zhang, Yu
中科院分区：
文献类型：
--
作者：
Jiao, Jingjing;Wei, Yan;Zhang, Yu
研究了富含A型原花青素的蔓越莓浓缩物（CBC）的抗衰老和氧化还原状态调节作用，并与富含B型原花青素的葡萄籽提取物（GSE）进行了比较。使用Q-提取质谱法，PAC二聚体A和B分别被鉴定为CBC和GSE的主要酚类化合物，而表儿茶素存在于两种提取物中。使用D-半乳糖诱导的衰老小鼠模型，以水溶性维生素E作为阳性对照，通过8周经口灌胃研究效果。CBC和GSE均使肝和脑硫代巴比妥酸反应物质和血浆8-异前列烷水平分别降低30- 57%、24-30%和11- 62%，并使脑和血浆单胺氧化酶活性分别降低27-59%和65- 71%。CBC可使肝脏谷胱甘肽过氧化物酶活性提高42%，而GSE使肝脏超氧化物歧化酶活性提高13%。因此，这两种提取物可能通过调节体内氧化还原状态发挥抗衰老作用。然而，都没有产生过氧化氢酶活性的任何影响。(C)2016爱思唯尔有限公司版权所有
We investigated the anti-aging and redox state regulation effects by A-type proanthocyanidins (PACs) rich cranberry concentrate (CBC) and its comparison with B-type PACs-rich grape seed extract (GSE). Using the Q-Extractive mass spectrometry, PACs dimer A and B were identified as predominant phenolic compounds of CBC and GSE, respectively, while epicatechin was present in both extracts. Using the D-galactose-induced aging mice model, effects were investigated via an 8-week oral gavage considering water-soluble vitamin E as the positive control. Both CBC and GSE reduced hepatic and brain thiobarbituric acid reactive substances, and plasma 8-isoprostane levels by 30-57%, 24-30% and 11-62%, respectively, and decreased brain and plasma monoamine oxidase activities by 27-59% and 65-71%, respectively. CBC could improve hepatic glutathione peroxidase activity by 42%, while GSE increased hepatic superoxide dismutase activity by 13%. Therefore, both extracts exerted anti-aging effects probably via regulating in vivo redox state. However, neither generated any effect on catalase activities. (C) 2016 Elsevier Ltd. All rights reserved.