New tachykinin peptides and nociception
New tachykinin peptides and nociception
复制标题
DOI：
10.1016/j.jdsr.2012.11.002
复制
发表时间：
2013-02
影响因子：
6.6
通讯作者：
T. Nishimori;R. Naono-Nakayama;T. Ikeda
中科院分区：
文献类型：
--
作者：
T. Nishimori;R. Naono-Nakayama;T. Ikeda
血激肽-1（HK-1）和内皮激肽是从哺乳动物新的速激肽基因TAC 4预测的肽。来自大鼠/小鼠HK-1和人HK-1的氨基酸序列不相同;然而，通过脑室内或鞘内施用HK-1诱导的效应通过用神经激肽1（NK 1）受体、P物质（SP）受体的拮抗剂处理而减弱，表明HK-1是NK 1受体的激动剂。另一方面，越来越多的证据表明HK-1和SP的药理学特性总是不相同的，这表明HK-1优选的受体可能参与HK-1的作用。内皮激肽衍生自人TAC 4，由四种内皮激肽组成，即内皮激肽A（EKA）、内皮激肽B（EKB）、内皮激肽C（EKC）和内皮激肽D（EKD）。鞘内注射EKA/B（EKA和EKB共有的C端十肽）和SP引起的效应非常相似，而SP和EKA/B的效应被EKC/D（EKC和EKD共有的C端十二肽）抑制。EKC/D的这种抑制作用来自羧基端的亮氨酸。提示HK-1和EKA/B对伤害性信息加工中的NK 1受体有激动作用，而EKC/D对伤害性信息加工中的NK 1受体有拮抗作用。
Hemokinin-1 (HK-1) and endokinins are peptides predicted from a new mammalian tachykinin gene, TAC4. The amino acid sequences derived from rat/mouse HK-1 and human HK-1 are not identical; however, the effects induced by intracerebroventricular or intrathecal administration of HK-1 are attenuated by treatment with antagonists of neurokinin 1 (NK1) receptor, substance P (SP) receptor, indicating that HK-1 is an agonist of the NK1 receptor. On the other hand, a growing body of evidence indicates that pharmacological characteristics of HK-1 and SP are always not identical, suggesting that the HK-1-preferred receptor may be involved in the effects of HK-1. Endokinins are derived from human TAC4 and consist of four endokinins, endokinin A (EKA), endokinin B (EKB), endokinin C (EKC) and endokinin D (EKD). Effects induced by intrathecal administration of EKA/B (the common C-terminal decapeptide in EKA and EKB) and SP were very similar, while the effects of SP and EKA/B were inhibited by EKC/D (the common C-terminal duodecapeptide in EKC and EKD). This inhibitory effect of EKC/D was derived from leucine at the carboxyl-terminus. These findings suggest that HK-1 and EKA/B have an agonistic effect, while EKC/D has an antagonistic effect on the NK1 receptor in nociceptive processing.