Spontaneous abortion in dry cleaning workers potentially exposed to perchloroethylene
Spontaneous abortion in dry cleaning workers potentially exposed to perchloroethylene
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DOI：
10.1136/oem.54.12.848
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发表时间：
1997-12-01
影响因子：
4.9
通讯作者：
Brookes, M
中科院分区：
文献类型：
--
作者：
Doyle, P;Roman, E;Brookes, M
目的：调查英国使用四氯乙烯溶剂的干洗店工作与自然流产之间的关系。方法：对7305名目前或以前受雇于英国干洗店或洗衣店的16岁至45岁女性的生殖结局进行回顾性职业研究。工作场所暴露和生殖结果的数据是通过邮寄调查获得的。报告的自然流产样本从医疗记录中得到了验证。在这项研究中，由于没有妇女个人剂量的数据，机器操作员和NaN操作员被用作干洗单位暴露于四氯乙烯的替代者，结果--现任干洗单位工人的应答率(78%)高于过去干洗单位工人的应答率(46%)。同样，现任洗衣工人的回应率(65%)高于过去洗衣工人的回应率(40%)。总体而言，受访者的生育特征与预期相似。然而，对怀孕时接触的检查表明，自然流产率根据妇女在怀孕期间或怀孕前三个月所做的工作类型而有所不同：不接触干洗或洗衣工作的孕妇自然流产率最低(10.9%)，接触洗衣工作的妇女自然流产率较高(13.4%)，接触干洗工作的妇女自然流产率更高(14.8%)。在接受干洗的孕妇组中，如果妇女报告她在怀孕时作为操作员(17.1%)而不是非操作员(11.6%)工作，这一比例更高。1980-1995年期间调整的优势比显示操作员的风险比非操作员高50%以上(p=0.04)，这两种工作的体力需求可能是相似的，当干洗员的工作与怀孕期间不在干洗或洗衣房工作时，发现风险更高，非操作工接触干洗店与任何额外的风险无关。结论--在怀孕期间或之前三个月在干洗店工作的自称操作员的妇女报告其妊娠以自然流产结束的可能性约为自称非操作员的妇女的一半。
Objectives-To investigate the association between spontaneous abortion and work within dry cleaning units in the United Kingdom where the solvent perchloroethylene is used.Methods-A retrospective occupational study of reproductive outcome in 7305 women aged 16 and 45 years, who were currently or previously employed in dry cleaning or laundry units in the United Kingdom. Data on workplace exposures and reproductive outcome were obtained by postal survey. A sample of reported spontaneous abortions was validated from medical records. Machine operator versus nan-operator was used as a surrogate for exposure to perchloroethylene in dry cleaning units as no data on individual doses were available for women in this study,Results-The response rate tvas higher for current workers of dry cleaning units (78%), than for past workers of dry cleaning units (46%). Similarly, the response for current laundry workers (65%) was higher than that for past laundry workers (40%). Overall, the reproductive characteristics of the respondents were similar to expectation. Examination of exposure at the time of pregnancy, however, showed that the rate of spontaneous abortion varied according to the type of work the women did during the pregnancy or in the three months before conception: being lowest for pregnancies not exposed to either dry cleaning or laundry work (10.9%), higher for those exposed to laundry work (13.4%), and higher still for those exposed to dry cleaning work (14.8%). Within the group of pregnancies exposed to dry cleaning, the proportion was higher if the woman reported that she worked as an operator at the time of the pregnancy (17.1%) rather than as a non-operator (11.6%). Adjusted odds ratios for the period 1980-95 showed that the risk was over 50% higher in operators than non-operators (p=0.04), The physical demands of the two jobs are likely to be similar, A higher risk was found when work as a dry cleaning operator was compared with no work in either dry cleaning or laundry units during pregnancy, Exposure to dry cleaning as a non-operator was not associated with any excess risk.Conclusions-Women who worked in dry cleaning shops at the time of their pregnancy or in the three months before who described themselves as operators were about half as likely again to report that their pregnancy ended in a spontaneous abortion than women who described themselves as non-operators.